WD repeat-containing protein: Difference between revisions

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*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.
*'''WD repeat-containing protein 48 and 20''' act as regulators of deubiquinating complexes.


*'''WD repeat-containing protein 41''' is the non-catalytic component of C9orf72-SMCR8 complex which regulates autophagy<ref>PMID:27193190</ref>.  <br />
*'''WD repeat-containing protein 55''' is a modulator of rRNA synthesis.  <br />
*'''WD repeat-containing protein 61''' is a component of PAF1 complex which functions during RNA transcription.  <br />
*'''WD repeat-containing protein 91''' functions as negative regulator of the PI3 kinase/PI3K activity in endosomal transport<ref>PMID:27126989</ref>.  <br />
*'''WD repeat-containing protein 92''' is a modulator of apoptosis.  <br />
*'''WD repeat-containing protein SLP1''' is required for mad2-dependent spindle checkpoint activation.  <br />
*'''WD repeat protein CSA''' or '''DNA excision repair protein ERCC-8''' is part of the transcription-coupled repair complex<ref>PMID:32355176</ref>.  <br />
== Disease ==
== Disease ==
Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.
Mutant WDR is involved in triple-A syndrome<ref>PMID:11062474</ref>.
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== Structural highlights ==
== Structural highlights ==
The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.
The <scene name='70/709459/Cv/4'>histone Arg2 residue inserts into the central pore</scene> of the WDR5 β-propellor structure acting like an anchoring pin <scene name='70/709459/Cv/3'>forming numerous hydrogen bonds and cation-π interactions</scene><ref>PMID:16946699</ref>. Water molecules are shown as red spheres.
 
== 3D Structures of WD-repeat protein ==
[[WD-repeat protein 3D structures]]
</StructureSection>
</StructureSection>


== 3D Structures of WD-repeat protein ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*WDR5
**[[2gnq]], [[2h68]], [[2h14]], [[2h9l]] – hWDR5 – human<br />
**[[3mxx]], [[3n0d]], [[3n0e]] – hWDR5 (mutant)<br />
**[[3smr]], [[3ur4]], [[4ia9]], [[4qqe]], [[4ql1]], [[5eal]], [[5eam]], [[5eap]], [[5ear]] – hWDR5 + piperazine derivative<br />
**[[6u5m]], [[6u5y]], [[6u6w]], [[6u80]], [[6u8b]], [[6u8l]], [[6u8o]] – hWDR5 + sulfonamide inhibitor<br />
**[[6ufx]], [[6ucs]], [[6pg3]], [[6pg4]], [[6pg5]], [[6pg6]], [[6pg7]], [[6pg8]], [[6pg9]], [[6pga]], [[6pgb]], [[6pgc]], [[6pgd]], [[6pge]], [[6pgf]], [[5vfc]], [[6dar]], [[6das]], [[6d9x]], [[6dai]], [[6dak]], [[6e1z]], [[6e1y]], [[6e22]], [[6e23]] – hWDR5 + inhibitor<br />
**[[2cnx]], [[2co0]], [[2h6k]], [[2h6n]], [[2h6q]], [[2h13]], [[2h9m]], [[2h9n]], [[2h9p]], [[2g99]], [[2g9a]], [[2o9k]], [[3psl]], [[4a7j]] – hWDR5 + histone H3 peptide<br />
**[[4gm3]], [[4gm8]], [[4gm9]], [[4gmb]] – hWDR5 + peptide inhibitor<br />
**[[2xl2]], [[2xl3]] – hWDR5 + retinoblastoma-binding protein 5 peptide<br />
**[[4o45]] – hWDR5 + influenza NS1 C-terminal<br />
**[[4cy1]] – hWDR5 + KAT8 regulatory NSL complex subunit 1+2 peptides<br />
**[[4cy2]] – hWDR5 + KAT8 regulatory NSL complex subunit 1 peptide<br />
**[[4y7r]] – hWDR5 + Myc MbIIIb peptide<br />
**[[3eg6]], [[3emh]], [[3uvk]], [[3uvl]], [[3uvm]], [[3uvn]], [[3uvo]], [[4erq]], [[4ery]], [[4es0]], [[4esg]], [[4ewr]], [[5sxm]] – hWDR5 + MLL peptide<br />
**[[4erz]] – hWDR5 + MLL4<br />
**[[6kiv]], [[6kiz]], [[6kiu]], [[6kix]] – hWDR5 in MLL1-ubNCP complex - Cryo EM<br />
**[[6kiw]] – hWDR5 in MLL3-ubNCP complex - Cryo EM<br />
**[[6pww]], [[6pwv]] – hWDR5 + MLL1 + RbBP5 + histones - Cryo EM<br />
**[[6byn]] – hWDR5 + monobody<br />
**[[3p4f]] – hWDR5 + retinoblastoma-binding protein 5 peptide + MLL peptide<br />
**[[6iam]] – hWDR5 + small ubiquitin-related modifier 5<br />
*WDR9
**[[2q2e]] – hWDR9 residues 1310-1430<br />
*WDR12
**[[6p0q]] – hWDR12 UBL domain residues 1-87<br />
**[[6n31]] – hWDR12 residues 90-422<br />
*WDR20
**[[5k19]] – hWDR20<br />
*WDR33 or pre-mRNA 3' end processing protein WDR33
**[[6f9n]] – hWDR33 residues 35-410 + CPSF160<br />
**[[6urg]] – hWDR33 + CPSF160 + CPSF30 + CPSF100 - Cryo EM<br />
**[[6fbs]], [[6fuw]], [[6uro]] – hWDR33 + CPSF160 + CPSF30 + PAS motif - Cryo EM<br />
*WDR48
**[[5cvl]] – hWDR48 <br />
**[[5l8e]] – hWDR48 + peptide<br />
**[[5l8w]], [[5cvn]], [[5cvo]] – hWDR48 + ubiquitin + ubiquitin carboxyl-terminal hydrolase<br />
**[[5k1a]], [[5k1b]] – hWDR48 + ubiquitin carboxyl-terminal hydrolase<br />
**[[5k1c]], [[6jlq]] – hWDR48 + WDR20 + ubiquitin carboxyl-terminal hydrolase<br />
*WDR60
**[[6rlb]], [[6sc2]] – hWDR60 + WDR34 + dynein + O6-alkylguanine-DNA alkyktransferase - Cryo EM<br />
*WDR61
**[[3ow8]] – hWDR61<br />
*WDR91
**[[6vyc]] – hWDR91 residues 392-747<br />
*WDR92
**[[3i2n]] – hWDR92<br />
*WDR SLP1
**[[4aez]] – WDR + mitotic spindle checkpoint component mad2-mad3 - fission yeast <br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 07:30, 4 April 2024

Human WD-repeat protein 5 (deepskyblue) complex with histone H3 peptide (magenta) (PDB code 2h9m)

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References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman

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