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==Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA==
==Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA==
<StructureSection load='2h3c' size='340' side='right'caption='[[2h3c]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2h3c' size='340' side='right'caption='[[2h3c]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2h3c]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H3C FirstGlance]. <br>
<table><tr><td colspan='2'>[[2h3c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H3C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H3C FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2h3a|2h3a]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3c OCA], [http://pdbe.org/2h3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h3c RCSB], [http://www.ebi.ac.uk/pdbsum/2h3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3c OCA], [https://pdbe.org/2h3c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h3c RCSB], [https://www.ebi.ac.uk/pdbsum/2h3c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h3c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCDA_ECOLI CCDA_ECOLI] Antitoxin component of a toxin-antitoxin (TA) module which inhibits the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Labile antitoxin with a half-life of about 1 hour in the presence of CcdB. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. The N-terminal 36 residues are not required for rejuventation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB.<ref>PMID:6327993</ref> <ref>PMID:2651399</ref> <ref>PMID:6308648</ref> <ref>PMID:2615761</ref> <ref>PMID:1324324</ref> <ref>PMID:8604132</ref> <ref>PMID:19647513</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Keller, W]]
[[Category: Keller W]]
[[Category: Madl, T]]
[[Category: Madl T]]
[[Category: Melderen, L Van]]
[[Category: Oberer M]]
[[Category: Oberer, M]]
[[Category: Respondek M]]
[[Category: Respondek, M]]
[[Category: Van Melderen L]]
[[Category: Zangger, K]]
[[Category: Zangger K]]
[[Category: Immune system-dna complex]]
[[Category: Ribbon-helix-helix]]
Retrieved from "https://proteopedia.org/2h3c"