Condensin: Difference between revisions
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<StructureSection load=' | <StructureSection load='5oqn' size='340' side='right' caption='Yeast SMC subunit 2 (green) and subunit 3 (grey) complex with DNA (PDB code [[5oqn]]' scene=''> | ||
== Function == | == Function == | ||
'''Condensin''' or '''structural maintenance of chromosome protein''' (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation<ref>PMID:28181049</ref>. SMC exhibits the ability to super-coil DNA<ref>PMID:23218009</ref>. SMC of ''E. coli'' is named '''MukB''' or '''Chromosome partition protein A'''. SMC is found in species from bacteria to human. SMC | '''Condensin''' or '''structural maintenance of chromosome protein''' (SMC) is required for correctly package and divide the cell's genome. SMC uses ATP to affect conformational changes in DNA, to correct DNA compaction, organization and segregation<ref>PMID:28181049</ref>. SMC exhibits the ability to super-coil DNA<ref>PMID:23218009</ref>. SMC of ''E. coli'' is named '''MukB''' or '''Chromosome partition protein A'''. '''MukE''' and '''MukF''' are associated with MukB. SMC is found in species from bacteria to human. SMC and cohesin which share structural similarities, are essential for separting the genome into daughter cells during cell division. SMC reorganizes chromsomes into their compact mitotic structure while cohesin glues replicated sister chromatids together until they split at anaphase<ref>PMID:12838344</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
SMC is a multisubunit complex. In vertebrates condensin complex is formed from the association of SMC2 and SMC4 subunits. SMC2 and SMC4 contain 3 domains: head domain forming | SMC is a multisubunit complex. In vertebrates condensin complex is formed from the association of SMC2 and SMC4 subunits. SMC2 and SMC4 contain 3 domains: head domain forming an ATPase, a long coiled-coil region and a hinge domain which facilitates SMC2/SMC4 dimerization. | ||
</StructureSection> | </StructureSection> | ||
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**[[6qj2]] – CtSMC head domain + Brn1<br /> | **[[6qj2]] – CtSMC head domain + Brn1<br /> | ||
**[[3zgx]] – BsSMC head domain + segregation and condensation protein – ''Bacillus subtilis''<br /> | **[[3zgx]] – BsSMC head domain + segregation and condensation protein – ''Bacillus subtilis''<br /> | ||
**[[5xg3]] – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein <br /> | **[[5xg3]] – BsSMC head domain (mutant)+ coiled-coil domain + segregation and condensation protein + ATPγS<br /> | ||
**[[1xew]] – PfSMC head domain – ''Pyrococcus furiosus''<br /> | **[[1xew]] – PfSMC head domain – ''Pyrococcus furiosus''<br /> | ||
**[[1xex]] – PfSMC head domain (mutant)<br /> | **[[1xex]] – PfSMC head domain (mutant)<br /> | ||
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**[[1qhl]] – EcMukB N-terminal 1-227 <br /> | **[[1qhl]] – EcMukB N-terminal 1-227 <br /> | ||
**[[3rpu]] – EcMukE N-terminal * MukF N-terminal <br /> | **[[3rpu]] – EcMukE N-terminal * MukF N-terminal <br /> | ||
**[[3euj]], [[3euk]] – MukB head domain (mutant) * MukF residues 292-443 + | **[[3euj]], [[3euk]] – MukB head domain (mutant) * MukF residues 292-443 + ATPγS - ''Haemophilus ducreyi''<br /> | ||
}} | }} | ||
== References == | == References == | ||
