1b03: Difference between revisions

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[[Image:1b03.gif|left|200px]]


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==SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE==
The line below this paragraph, containing "STRUCTURE_1b03", creates the "Structure Box" on the page.
<StructureSection load='1b03' size='340' side='right'caption='[[1b03]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1b03]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B03 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b03 OCA], [https://pdbe.org/1b03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b03 RCSB], [https://www.ebi.ac.uk/pdbsum/1b03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b03 ProSAT]</span></td></tr>
{{STRUCTURE_1b03| PDB=1b03  |  SCENE= }}
</table>
 
== Function ==
'''SOLUTION STRUCTURE OF THE ANTIBODY-BOUND HIV-1IIIB V3 PEPTIDE'''
[https://www.uniprot.org/uniprot/Q79428_9HIV1 Q79428_9HIV1]
 
<div style="background-color:#fffaf0;">
 
== Publication Abstract from PubMed ==
==Overview==
The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.
The refined solution structure of an 18-residue HIV-1IIIB V3 peptide in complex with the Fv fragment of an anti-gp120 antibody reveals an unexpected type VI beta-turn comprising residues RGPG at the center of a beta-hairpin. The central glycine and proline of this turn are linked by a cis peptide bond. The residues of the turn interact extensively with the antibody Fv. 15N[1H] NOE measurements show that the backbone of the peptide, including the central QRGPGR loop, is well ordered in the complex. The solution structure is significantly different from the X-ray structures of HIV-1MN V3 peptides bound to anti-peptide antibodies. These differences could be due to a two-residue (QR) insertion preceding the GPGR sequence in the HIV-1IIIB strain, and the much longer peptide epitope immobilized by the anti-gp120 antibody.


==About this Structure==
A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide.,Tugarinov V, Zvi A, Levy R, Anglister J Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:10201400<ref>PMID:10201400</ref>
1B03 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B03 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
A cis proline turn linking two beta-hairpin strands in the solution structure of an antibody-bound HIV-1IIIB V3 peptide., Tugarinov V, Zvi A, Levy R, Anglister J, Nat Struct Biol. 1999 Apr;6(4):331-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10201400 10201400]
</div>
[[Category: Single protein]]
<div class="pdbe-citations 1b03" style="background-color:#fffaf0;"></div>
[[Category: Anglister, J.]]
== References ==
[[Category: Levy, R.]]
<references/>
[[Category: Tugarinov, V.]]
__TOC__
[[Category: Zvi, A.]]
</StructureSection>
[[Category: P1053 structure]]
[[Category: Human immunodeficiency virus 1]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:54:06 2008''
[[Category: Large Structures]]
[[Category: Anglister J]]
[[Category: Levy R]]
[[Category: Tugarinov V]]
[[Category: Zvi A]]
Retrieved from "https://proteopedia.org/1b03"