2buj: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
New page: left|200px<br /> <applet load="2buj" size="450" color="white" frame="true" align="right" spinBox="true" caption="2buj, resolution 2.60Å" /> '''CRYSTAL STRUCTURE O...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(21 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2buj.gif|left|200px]]<br />
<applet load="2buj" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2buj, resolution 2.60&Aring;" />
'''CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE'''<br />


==About this Structure==
==Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine==
2BUJ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL and STU as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BUJ OCA]].
<StructureSection load='2buj' size='340' side='right'caption='[[2buj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2buj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BUJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2buj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2buj OCA], [https://pdbe.org/2buj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2buj RCSB], [https://www.ebi.ac.uk/pdbsum/2buj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2buj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STK16_HUMAN STK16_HUMAN] Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.<ref>PMID:10364453</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/2buj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2buj ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Amos, A.]]
[[Category: Amos A]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Ball, L.J.]]
[[Category: Ball LJ]]
[[Category: Bullock, A.]]
[[Category: Bullock A]]
[[Category: Debreczeni, J.E.]]
[[Category: Debreczeni JE]]
[[Category: Delft, F.Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Eswaran J]]
[[Category: Eswaran, J.]]
[[Category: Fedorov O]]
[[Category: Fedorov, O.]]
[[Category: Filippakopoulos P]]
[[Category: Filippakopoulos, P.]]
[[Category: Kavanagh K]]
[[Category: Kavanagh, K.]]
[[Category: Knapp S]]
[[Category: Knapp, S.]]
[[Category: Sobott F]]
[[Category: Sobott, F.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: CL]]
[[Category: STU]]
[[Category: atp-binding]]
[[Category: kinase]]
[[Category: lipoprotein]]
[[Category: myristate]]
[[Category: palmitate]]
[[Category: phosphorylation]]
[[Category: serine/threonine-protein kinase]]
[[Category: transferase]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 17:49:43 2007''
Retrieved from "https://proteopedia.org/2buj"