6upn: Difference between revisions
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==Endophilin B1 helical scaffold== | ==Endophilin B1 helical scaffold== | ||
<StructureSection load='6upn' size='340' side='right'caption='[[6upn]]' scene=''> | <StructureSection load='6upn' size='340' side='right'caption='[[6upn]], [[Resolution|resolution]] 10.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UPN OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6upn]] is a 48 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UPN FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 10Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6upn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6upn OCA], [https://pdbe.org/6upn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6upn RCSB], [https://www.ebi.ac.uk/pdbsum/6upn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6upn ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SHLB1_HUMAN SHLB1_HUMAN] May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).[UniProtKB:Q9JK48]<ref>PMID:11604418</ref> <ref>PMID:15452144</ref> <ref>PMID:17891140</ref> <ref>PMID:20643123</ref> <ref>PMID:21068542</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bhatt VS]] | [[Category: Bhatt VS]] | ||
[[Category: Sundborger-Lunna AC]] | [[Category: Sundborger-Lunna AC]] | ||
