5emw: Difference between revisions

<table><tr><td colspan='2'>[[5emw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EMW FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5emw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5emw OCA], [https://pdbe.org/5emw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5emw RCSB], [https://www.ebi.ac.uk/pdbsum/5emw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5emw ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TEAD3_HUMAN TEAD3_HUMAN] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>  

[[Category: Homo sapiens]]

[[Category: Cunningham CN]]

[[Category: Dey A]]

[[Category: Fairbrother WJ]]

[[Category: Gierke S]]

[[Category: Hannoush RN]]

[[Category: Murray J]]

[[Category: Noland CL]]

[[Category: Sagolla M]]

[[Category: Sandoval WN]]

[[Category: Schnier PD]]