5eou: Difference between revisions

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<StructureSection load='5eou' size='340' side='right'caption='[[5eou]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5eou' size='340' side='right'caption='[[5eou]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5eou]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EOU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EOU FirstGlance]. <br>
<table><tr><td colspan='2'>[[5eou]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EOU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eox|5eox]], [[5eoy|5eoy]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pilN, PA5043 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eou OCA], [https://pdbe.org/5eou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eou RCSB], [https://www.ebi.ac.uk/pdbsum/5eou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eou ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eou OCA], [http://pdbe.org/5eou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eou RCSB], [http://www.ebi.ac.uk/pdbsum/5eou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eou ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PILM_PSEAE PILM_PSEAE] Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus (PubMed:19857645, PubMed:19857646). In turn, associates with PilN and facilitates PilM functionally relevant structural changes that differentially impacts PilM binding to PilB, PilT, and PilC (PubMed:27022027).<ref>PMID:19857645</ref> <ref>PMID:19857646</ref> <ref>PMID:27022027</ref> [https://www.uniprot.org/uniprot/PILN_PSEAE PILN_PSEAE] Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus (PubMed:19857645, PubMed:19857646). In turn, associates with PilM and facilitates PilM functionally relevant structural changes (PubMed:27022027).<ref>PMID:19857645</ref> <ref>PMID:19857646</ref> <ref>PMID:27022027</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pseae]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Burrows, L]]
[[Category: Burrows L]]
[[Category: Calmettes, C]]
[[Category: Calmettes C]]
[[Category: Howell, L P]]
[[Category: Howell LP]]
[[Category: McCallum, M]]
[[Category: McCallum M]]
[[Category: Moraes, T]]
[[Category: Moraes T]]
[[Category: Robinson, H]]
[[Category: Robinson H]]
[[Category: Shah, M]]
[[Category: Shah M]]
[[Category: Tammam, S]]
[[Category: Tammam S]]
[[Category: Peptide binding protein]]
[[Category: Pilm]]
[[Category: Piln]]
[[Category: T4p]]
[[Category: Type iv pilus]]
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