6yrw: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 6yrw is ~~ON HOLD~~

==SHMT from Streptococcus thermophilus Tyr55Ser variant as internal aldimine and as non-covalent complex with D-Ser==

== Structural highlights ==

<table><tr><td colspan='2'>[[6yrw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YRW OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6YRW FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6yrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yrw OCA], [https://pdbe.org/6yrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yrw RCSB], [https://www.ebi.ac.uk/pdbsum/6yrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yrw ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

~~Authors: Petrillo, G., Hernandez, K., Bujons, J., Clapes, P., Uson, I.~~

==See Also==

*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]

~~Description~~: ~~SHMT from Streptococcus thermophilus Tyr55Ser variant as internal aldimine and as non-covalent complex with D-Ser~~

__TOC__

[[Category: ~~Unreleased Structures~~]]

</StructureSection>

[[Category: Bujons, J]]

[[Category: Large Structures]]

[[Category: ~~Uson, I~~]]

[[Category: Streptococcus thermophilus]]

[[Category: Hernandez, K]]

[[Category: Bujons J]]

[[Category: Petrillo, G]]

[[Category: Clapes P]]

[[Category: ~~Clapes, P~~]]

[[Category: Hernandez K]]

[[Category: Petrillo G]]

[[Category: Uson I]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6yrw is ON HOLD
+==SHMT from Streptococcus thermophilus Tyr55Ser variant as internal aldimine and as non-covalent complex with D-Ser==
+<StructureSection load='6yrw' size='340' side='right'caption='[[6yrw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6yrw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YRW FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yrw OCA], [https://pdbe.org/6yrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yrw RCSB], [https://www.ebi.ac.uk/pdbsum/6yrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yrw ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
-Authors: Petrillo, G., Hernandez, K., Bujons, J., Clapes, P., Uson, I.
+==See Also==
+*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
-Description: SHMT from Streptococcus thermophilus Tyr55Ser variant as internal aldimine and as non-covalent complex with D-Ser
+__TOC__
-[[Category: Unreleased Structures]]
+</StructureSection>
-[[Category: Bujons, J]]
+[[Category: Large Structures]]
-[[Category: Uson, I]]
+[[Category: Streptococcus thermophilus]]
-[[Category: Hernandez, K]]
+[[Category: Bujons J]]
-[[Category: Petrillo, G]]
+[[Category: Clapes P]]
-[[Category: Clapes, P]]
+[[Category: Hernandez K]]
+[[Category: Petrillo G]]
+[[Category: Uson I]]