6q1m: Difference between revisions

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<StructureSection load='6q1m' size='340' side='right'caption='[[6q1m]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
<StructureSection load='6q1m' size='340' side='right'caption='[[6q1m]], [[Resolution|resolution]] 1.24&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6q1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Wdv Wdv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q1M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Q1M FirstGlance]. <br>
<table><tr><td colspan='2'>[[6q1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Wheat_dwarf_virus Wheat dwarf virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Q1M FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.24&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">repA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10834 WDV])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6q1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q1m OCA], [http://pdbe.org/6q1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q1m RCSB], [http://www.ebi.ac.uk/pdbsum/6q1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q1m ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6q1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q1m OCA], [https://pdbe.org/6q1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6q1m RCSB], [https://www.ebi.ac.uk/pdbsum/6q1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6q1m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/REP_WDVS REP_WDVS] Essential for the replication of viral ssDNA. The closed circular ssDNA genome is first converted to a superhelical dsDNA. Rep binds a specific region at the genome origin of replication. It introduces an endonucleolytic nick within the conserved sequence 5'-TAATATTAC-3' in the intergenic region of the genome present in all geminiviruses, thereby initiating the rolling circle replication (RCR). Following cleavage, binds covalently to the 5'-phosphate of DNA as a tyrosyl ester. The cleavage gives rise to a free 3'-OH that serves as a primer for the cellular DNA polymerase. The polymerase synthesizes the (+) strand DNA by rolling circle mechanism. After one round of replication, a Rep-catalyzed nucleotidyl transfer reaction releases a circular single-stranded virus genome, thereby terminating the replication. Displays origin-specific DNA cleavage, nucleotidyl transferase, ATPase and helicase activities. Acts as an inhibitor of C-sense gene transcription (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Wdv]]
[[Category: Wheat dwarf virus]]
[[Category: Everett, B A]]
[[Category: Evans III RL]]
[[Category: Gordon, W R]]
[[Category: Everett BA]]
[[Category: III, R L.Evans]]
[[Category: Gordon WR]]
[[Category: Litzau, L A]]
[[Category: Litzau LA]]
[[Category: Shi, K]]
[[Category: Shi K]]
[[Category: Tompkins, K]]
[[Category: Tompkins K]]
[[Category: Huh motif]]
[[Category: Huh-tag]]
[[Category: Rep domain]]
[[Category: Replication]]
[[Category: Single stranded dna]]
[[Category: Ssdna]]
[[Category: Ssdna binding]]
[[Category: Viral protein]]
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