Synapsin: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1px2' size='340' side='right' caption='Rat synapsin 1 complex with ATP anc Ca++ ion (green) (PDB code 1px2)' scene=''> == Function == '''Synapsins''' (SYN) ... |
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<StructureSection load='1px2' size='400' side='right' caption='Rat synapsin 1 complex with ATP and Ca++ ion (green) (PDB code [[1px2]])' scene='84/843883/Cv/1'> | |||
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== Function == | == Function == | ||
'''Synapsins''' (SYN) are neuronal phosphoproteins which modulate neurotransmitter release at the pre-synaptic terminal by reversibly tethering synaptic vescicles to the actin cytoskeleton<ref>PMID:20438797</ref>. | '''Synapsins''' (SYN) are neuronal phosphoproteins which modulate neurotransmitter release at the pre-synaptic terminal by reversibly tethering synaptic vescicles to the actin cytoskeleton<ref>PMID:20438797</ref>. | ||
*'''Synapsin 1''' is involved in synapse formation<ref>PMID:9513186</ref>. | |||
*'''Synapsin 2''' is involved in axon formation. | |||
*'''Synapsin 3''' is involved in regulation of dopaminergic neurotransmission<ref>PMID:21827867</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both hydrogen bonds and Van-der Waals contacts with the protein<ref>PMID:14688264</ref>. | The 3D structure of the rat synapsin 1 complex with ATP shows the catalytically essential multifunctional loop surrounding the ATP which makes both <scene name='84/843883/Cv/4'>hydrogen bonds</scene> and <scene name='84/843883/Cv/5'>Van-der Waals contacts</scene> with the protein<ref>PMID:14688264</ref>. Water molecules are shown as red spheres. | ||
==3D structures of synapsin== | ==3D structures of synapsin== | ||
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**[[1auv]] - bSYN1A C-terminal 110-421 - bovine<br /> | **[[1auv]] - bSYN1A C-terminal 110-421 - bovine<br /> | ||
**[[1aux]] - bSYN1A C-terminal + ATPgS<br /> | **[[1aux]] - bSYN1A C-terminal + ATPgS<br /> | ||
**[[1pk8]], [[1px2]] - rSYN1 | **[[1pk8]], [[1px2]] - rSYN1 + ATP - rat<br /> | ||
*Synapsin 2 | *Synapsin 2 | ||
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== References == | == References == | ||
<references/> | <references/> | ||
</StructureSection> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
