Vm24 Scorpion Toxin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (3 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
==Introduction== | ==Introduction== | ||
Vm24 synthetic scorpion toxin is a peptide toxin isolated from ''Vaejovis mexicanus smithi'' scorpion venom. It is a potent inhibitor of Kv1.3 potassium channels of human T lymphocytes. Its high affinity and specificity for human lymphocytes makes it a candidate for the treatment of several autoimmune disorders. | '''Vm24''' synthetic scorpion toxin is a peptide toxin isolated from ''Vaejovis mexicanus smithi'' scorpion venom. It is a potent inhibitor of Kv1.3 potassium channels of human T lymphocytes. Its high affinity and specificity for human lymphocytes makes it a candidate for the treatment of several autoimmune disorders. | ||
[[Image:V24 APBS.png|300px|thumb|upright|left|alt=alt|APBS Electrostatic Surface of Vm24, [[2k9o]]]] | [[Image:V24 APBS.png|300px|thumb|upright|left|alt=alt|APBS Electrostatic Surface of Vm24, [[2k9o]]]] | ||
<Structure load='2k9o' size='350' frame='true' align='right' caption='Vm24 Scorpion Toxin [[2k9o]]' scene='Insert optional scene name here' /> | <Structure load='2k9o' size='350' frame='true' align='right' caption='Vm24 Scorpion Toxin [[2k9o]]' scene='Insert optional scene name here' /> | ||
| Line 19: | Line 19: | ||
==Medical Relevance== | ==Medical Relevance== | ||
Proliferation of T- cells can be blocked by blocking membrane K+ channels[https://www.pnas.org/content/96/19/10917]. Auto-immune diseases such as multiple sclerosis and type I diabetes mellitus involve autoreactive T-cell clones who's proliferation requires Kv1.3 channel activation. Other members of alpha-KTx peptides are blockers of Kv1.3 channels, but they also block other K+ channels. Most K+ channel blockers are highly toxic for this reason. Mice were tested with 50-200ug of Vm24 per mouse (20g body weight) and showed no symptoms of intoxication. Vm24 thus has high potential for use in the treatment of autoimmune diseases. | Proliferation of T- cells can be blocked by blocking membrane K+ channels[https://www.pnas.org/content/96/19/10917]. Auto-immune diseases such as multiple sclerosis and type I diabetes mellitus involve autoreactive T-cell clones who's proliferation requires Kv1.3 channel activation. Other members of alpha-KTx peptides are blockers of Kv1.3 channels, but they also block other K+ channels. Most K+ channel blockers are highly toxic for this reason. Mice were tested with 50-200ug of Vm24 per mouse (20g body weight) and showed no symptoms of intoxication. Vm24 thus has high potential for use in the treatment of autoimmune diseases. | ||
==References== | |||
Gurrola, G. B., Hernández-López, R. A., Rodríguez de la Vega, R. C., Varga, Z., Batista, C. V. F., Salas-Castillo, S. P., Panyi, G., del Río-Portilla, F., & Possani, L. D. (2012). Structure, Function, and Chemical Synthesis of Vaejovis mexicanus Peptide 24: A Novel Potent Blocker of Kv1.3 Potassium Channels of Human T Lymphocytes. Biochemistry, 51(19), 4049–4061. https://doi.org/10.1021/bi300060n<ref>https://pubmed-ncbi-nlm-nih-gov.ezproxy.uvm.edu/22540187/?from_single_result=Structure%2C+function%2C+and+chemical+synthesis+of+Vaejovis+mexicanus+peptide+24%3A+a+novel+potent+blocker+of+Kv1.3+potassium+channels+of+human+T+lymphocytes.&expanded_search_query=Structure%2C+function%2C+and+chemical+synthesis+of+Vaejovis+mexicanus+peptide+24%3A+a+novel+potent+blocker+of+Kv1.3+potassium+channels+of+human+T+lymphocytes.</ref> | |||
(2018). UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research, 47(D1), D506–D515. https://doi.org/10.1093/nar/gky1049<ref>https://www.uniprot.org/taxonomy/1562928</ref> | |||
<ref>https://www.uniprot.org/uniprot/?query=family%3A%22short+scorpion+toxin+superfamily%22&sort=score</ref><ref>https://www.uniprot.org/uniprot/?query=family:%22short+scorpion+toxin+superfamily.+Potassium+channel+inhibitor+family.+Alpha-KTx+23+subfamily%22&sort=score</ref> | |||
Lomize, M. A., Pogozheva, I. D., Joo, H., Mosberg, H. I., & Lomize, A. L. (2011). OPM database and PPM web server: resources for positioning of proteins in membranes. Nucleic Acids Research, 40(D1), D370–D376. https://doi.org/10.1093/nar/gkr703<ref>https://opm.phar.umich.edu/proteins/994</ref> | |||
Jensen, B. S., Odum, N., Jorgensen, N. K., Christophersen, P., & Olesen, S.-P. (1999). Inhibition of T cell proliferation by selective block of Ca2+-activated K+ channels. Proceedings of the National Academy of Sciences, 96(19), 10917–10921. https://doi.org/10.1073/pnas.96.19.10917<ref>https://www.pnas.org/content/96/19/10917</ref> | |||
