6w25: Difference between revisions
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<StructureSection load='6w25' size='340' side='right'caption='[[6w25]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='6w25' size='340' side='right'caption='[[6w25]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6w25]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6w25]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W25 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W25 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4J2:(2R)-2-AMINO-3-(NAPHTHALEN-2-YL)PROPANOIC+ACID'>4J2</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w25 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w25 OCA], [https://pdbe.org/6w25 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w25 RCSB], [https://www.ebi.ac.uk/pdbsum/6w25 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w25 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN] Obesity due to melanocortin 4 receptor deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/MC4R_HUMAN MC4R_HUMAN] Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).<ref>PMID:12646665</ref> <ref>PMID:25163632</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6w25" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6w25" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Alice Clark/BRCT|Alice Clark/BRCT]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Burdsall | [[Category: Pyrococcus abyssi GE5]] | ||
[[Category: Chen | [[Category: Synthetic construct]] | ||
[[Category: Cone | [[Category: Burdsall K]] | ||
[[Category: Gimenez | [[Category: Chen V]] | ||
[[Category: Han | [[Category: Cone RD]] | ||
[[Category: Hernandez | [[Category: Gimenez LE]] | ||
[[Category: McClary | [[Category: Han GW]] | ||
[[Category: Millhauser | [[Category: Hernandez CC]] | ||
[[Category: Mittal | [[Category: McClary K]] | ||
[[Category: Peisley | [[Category: Millhauser GL]] | ||
[[Category: Stauch | [[Category: Mittal SR]] | ||
[[Category: Stevens | [[Category: Peisley A]] | ||
[[Category: Stevens | [[Category: Stauch B]] | ||
[[Category: Wein | [[Category: Stevens RC]] | ||
[[Category: Williams | [[Category: Stevens SN]] | ||
[[Category: Wu | [[Category: Wein AH]] | ||
[[Category: Wu | [[Category: Williams SY]] | ||
[[Category: Yu | [[Category: Wu L]] | ||
[[Category: Zhao | [[Category: Wu Y]] | ||
[[Category: Yu J]] | |||
[[Category: Zhao S]] | |||
