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<StructureSection load='6yor' size='340' side='right'caption='[[6yor]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='6yor' size='340' side='right'caption='[[6yor]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6yor]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Wcpv Wcpv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YOR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YOR FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YOR FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6yla|6yla]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">S, 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2697049 WCPV])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yor OCA], [https://pdbe.org/6yor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yor RCSB], [https://www.ebi.ac.uk/pdbsum/6yor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yor ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yor OCA], [http://pdbe.org/6yor PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yor RCSB], [http://www.ebi.ac.uk/pdbsum/6yor PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yor ProSAT]</span></td></tr>
</table>
</table>
== Function ==
 
[[http://www.uniprot.org/uniprot/SPIKE_SARS2 SPIKE_SARS2]] attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.[HAMAP-Rule:MF_04099]<ref>PMID:32075877</ref> <ref>PMID:32142651</ref> <ref>PMID:32155444</ref>  mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099] Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]  
==See Also==
== References ==
*[[Antibody 3D structures|Antibody 3D structures]]
<references/>
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Wcpv]]
[[Category: Carrique L]]
[[Category: Carrique, L]]
[[Category: Duyvesteyn HME]]
[[Category: Duyvesteyn, H M.E]]
[[Category: Fry EE]]
[[Category: Fry, E E]]
[[Category: Huo J]]
[[Category: Huo, J]]
[[Category: Malinauskas T]]
[[Category: Malinauskas, T]]
[[Category: Owens R]]
[[Category: Owens, R]]
[[Category: Ren J]]
[[Category: Ren, J]]
[[Category: Ruza RR]]
[[Category: Ruza, R R]]
[[Category: Shah PNM]]
[[Category: Shah, P N.M]]
[[Category: Stuart DI]]
[[Category: Stuart, D I]]
[[Category: Zhao Y]]
[[Category: Zhao, Y]]
[[Category: Zhou D]]
[[Category: Zhou, D]]
[[Category: Complex]]
[[Category: Cr3022]]
[[Category: Rbd]]
[[Category: Sars-cov-2 spike protein]]
[[Category: Viral protein]]

Latest revision as of 05:52, 3 July 2025

Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab

6yor, resolution 3.30Å

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