5fpm: Difference between revisions

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<StructureSection load='5fpm' size='340' side='right'caption='[[5fpm]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
<StructureSection load='5fpm' size='340' side='right'caption='[[5fpm]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5fpm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FPM FirstGlance]. <br>
<table><tr><td colspan='2'>[[5fpm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FPM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IWT:5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL'>IWT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fp5|5fp5]], [[5fp6|5fp6]], [[5fpd|5fpd]], [[5fpe|5fpe]], [[5fpn|5fpn]], [[5fpo|5fpo]], [[5fpr|5fpr]], [[5fps|5fps]], [[5fpt|5fpt]], [[5fpy|5fpy]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IWT:5-PHENYL-1,3,4-OXADIAZOLE-2-THIOL'>IWT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpm OCA], [http://pdbe.org/5fpm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpm RCSB], [http://www.ebi.ac.uk/pdbsum/5fpm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fpm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpm OCA], [https://pdbe.org/5fpm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fpm RCSB], [https://www.ebi.ac.uk/pdbsum/5fpm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fpm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HSP72_HUMAN HSP72_HUMAN]] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.  
[https://www.uniprot.org/uniprot/HSP72_HUMAN HSP72_HUMAN] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jhoti, H]]
[[Category: Jhoti H]]
[[Category: Ludlow, R F]]
[[Category: Ludlow RF]]
[[Category: Patel, S]]
[[Category: Patel S]]
[[Category: Saini, H K]]
[[Category: Saini HK]]
[[Category: Tickle, I J]]
[[Category: Tickle IJ]]
[[Category: Verdonk, M]]
[[Category: Verdonk M]]
[[Category: Alternate binding site]]
[[Category: At809]]
[[Category: Chaperone]]
[[Category: Fragment screening]]
[[Category: Heat shock]]
[[Category: Heat shock-related protein]]
[[Category: Hsp70]]
[[Category: Hspa2]]
[[Category: Protein-ligand complex]]
Retrieved from "https://proteopedia.org/5fpm"