Activin: Difference between revisions
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<StructureSection load='5hlz' size='340' side='right' caption='Human activin A (PDB code [[5hlz]])' scene=''> | <StructureSection load='5hlz' size='340' side='right' caption='Human activin A pro domain (grey, pink) and mature domain (green, yellow) (PDB code [[5hlz]])' scene=''> | ||
__TOC__ | |||
== Function == | |||
'''Activin A''' or '''inhibitin β chain A''' (ActA) is a member of the TGF-β superfamily that inhibits the proliferation of breast cancer cells. Activin interacts with activin receptors to induce phosphorylation of intracellular signalling molecules which regulate the transcription of many genes in a cell- and tissue-specific manner<ref>PMID:16140969</ref>. | |||
See also [[TGF beta signaling pathway]]. | |||
== Relevance == | == Relevance == | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of activin | ==3D structures of activin== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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[[2b0u]], [[2arp]], [[2p6a]] - hActA mature domain + follistatin<br /> | [[2b0u]], [[2arp]], [[2p6a]] - hActA mature domain + follistatin<br /> | ||
[[3b4v]] - hActA mature domain + follistatin-like 3<br /> | [[3b4v]] - hActA mature domain + follistatin-like 3<br /> | ||
[[6y6n]], [[6y6o]] - hActA mature domain + diazepine derivative<br /> | |||
[[7u5o]] - hActB + BMPR-2<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 10:17, 8 September 2024
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3D structures of activin
Updated on 08-September-2024
TGF beta signaling pathway, 5hly - hActA - human
2arv - hActA mature domain residues 311-426
1nys, 1nyu, 1s4y - hActA mature domain + Acvr2B LBD
2b0u, 2arp, 2p6a - hActA mature domain + follistatin
3b4v - hActA mature domain + follistatin-like 3
6y6n, 6y6o - hActA mature domain + diazepine derivative
7u5o - hActB + BMPR-2
