CFTR inhibitory factor: Difference between revisions
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<StructureSection load='5tnh' size='340' side='right' caption=' | <StructureSection load='5tnh' size='340' side='right' caption='CFTR inhibitory factor complex with an intermediate (PDB code [[5tnh]])' scene=''> | ||
== Function == | == Function == | ||
''' | '''CFTR inhibitory factor''' (Cif) is a virulance factor which catalyzes epoxide hydrolysis. ''Pseudomonas aeruginosa'' secretes Cif which causes the loss the ion channel Cystic Fibrosis Transmembrane conductance Regulator (CFTR) which is required for airway mucocilliary defense of the host cell<ref>PMID:26136396</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between Cif and the epoxy hydrolysis intermediate shows the coordination by His and Tyr esidues which facilitate the epoxyde opening by a nucleophilic attack of Asp creating a hydroxyalkyl-enzyme intermediate<ref>PMID:28392259</ref>. | |||
</StructureSection> | </StructureSection> | ||
==3D structures of | ==3D structures of CFTR inhibitory factor== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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[[4eus]] - PaCif + hexanediol<br /> | [[4eus]] - PaCif + hexanediol<br /> | ||
[[4yx9]], [[5hka]], [[5hkb]], [[5hk9]] - PaCif + inhibitor <br /> | [[4yx9]], [[5hka]], [[5hkb]], [[5hk9]] - PaCif + inhibitor <br /> | ||
[[8ee2]], [[8eln]], [[8evd]], [[8f6u]], [[8f6v]], [[8gjr]] - PaCif + nanobody<br /> | |||
== References == | == References == | ||
