CFTR inhibitory factor

spinqualitylabelsall models CFTR inhibitory factor complex with an intermediate (PDB code 5tnh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CFTR inhibitory factor (Cif) is a virulance factor which catalyzes epoxide hydrolysis. Pseudomonas aeruginosa secretes Cif which causes the loss the ion channel Cystic Fibrosis Transmembrane conductance Regulator (CFTR) which is required for airway mucocilliary defense of the host cell. Structural highlights The 3D structure of the complex between Cif and the epoxy hydrolysis intermediate shows the coordination by His and Tyr esidues which facilitate the epoxyde opening by a nucleophilic attack of Asp creating a hydroxyalkyl-enzyme intermediate.

3D structures of CFTR inhibitory factor

Updated on 22-January-2025

3kd2 - PaCif - Pseudomonas aeruginosa
3kda, 4dm7, 4dln, 4dmf, 4dmh, 4dmk, 3pi6, 4dmc - PaCif (mutant)
5tnh, 5tng, 5tni, 5tnl, 5tnk, 5tnn, 5tnm, 5tnd, 5tnf, 5tne, 5tnp, 5tnr, 5tnq, 5tns, 5tnj, 5jyc, 4dno, 4dnf - PaCif (mutant) + intermediate
4ehb - PaCif (mutant) + epoxyhexane
4eus - PaCif + hexanediol
4yx9, 5hka, 5hkb, 5hk9 - PaCif + inhibitor
8ee2, 8eln, 8evd, 8f6u, 8f6v, 8gjr - PaCif + nanobody

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