Sandbox UC 9: Difference between revisions

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==Title==

===subtitle===

For an introduction to the structure and function of lipase, please see the article [[Lipase]]. This ''Lipase lid morph'' article is a supplement to the main article on [[Lipase]].

''Candida rugosa'' lipase (triacylglycerol hydrolase) has been observed in two conformations, with the "lid" (residues 66-92<ref name='2states1994' />) closed ([[1trh]]) or open ([[1lpm]])<ref name='2states1994'>PMID: 8142901</ref>.

*Closed LID (<scene name='Lipase_lid_morph/Lightseagreen_hinge/1'>restore initial scene</scene>).

*<scene name='Lipase_lid_morph/Lightseagreen_hinge/4'>Open</scene> LID with inhibitor (1R)-menthyl hexyl phosphonate (C O P).

A morph<ref>This is a [[Morphs#Linear_Interpolation|linear interpolation morph]]. The 14-model PDB file is [[Image:Morph-linear-1trh-1lpm.pdb.gz]].</ref> shows the lid opening and closing.

*<scene name='Lipase_lid_morph/Lightseagreen_hinge/2'>Cartoon morph</scene> (LID).

*<scene name='Lipase_lid_morph/Lightseagreen_hinge/3'>Spacefilling morph</scene> (LID, catalytic triad: Ser209, Glu341, and His449<ref name='2states1994' />).

When the lid is closed, the enzyme surface is largely {{Template:ColorKey_Polar}}. When the lid opens, a {{Template:ColorKey_Hydrophobic}} pocket is exposed with the catalytic triad in the bottom.

*<scene name='Lipase_lid_morph/Lightseagreen_hinge/5'>Spacefilling morph</scene> ({{Template:ColorKey_Polar}}, {{Template:ColorKey_Hydrophobic}}, catalytic triad: Ser209, Glu341, and His449<ref name='2states1994' />).

==See Also==

*[[Lipase]], the main article in Proteopedia.

*[[Molecular Playground/Pancreatic Lipase]]

*[http://en.wikipedia.org/wiki/Lipase Lipase in Wikipedia]

==Notes and References==

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+<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
+==Title==
+===subtitle===
+ <ref>PMID:3023912</ref>
+ <ref>PMID:7120407</ref>
+ <ref>PMID: 2337600</ref>
+ <ref>PMID:7308213</ref>
+ <ref>PMID:17615299</ref>
+<Structure load='' size='400' frame='true' align='right' caption='Candida rugosa lipase ([[1trh]], [[1lpm]]).' scene='Lipase_lid_morph/Lightseagreen_hinge/1' />
+For an introduction to the structure and function of lipase, please see the article [[Lipase]]. This ''Lipase lid morph'' article is a supplement to the main article on [[Lipase]].
+''Candida rugosa'' lipase (triacylglycerol hydrolase) has been observed in two conformations, with the "lid" (residues 66-92<ref name='2states1994' />) closed ([[1trh]]) or open ([[1lpm]])<ref name='2states1994'>PMID: 8142901</ref>.
+*Closed <font color='lightseagreen'><b>LID</b></font> (<scene name='Lipase_lid_morph/Lightseagreen_hinge/1'>restore initial scene</scene>).
+*<scene name='Lipase_lid_morph/Lightseagreen_hinge/4'>Open</scene> <font color='lightseagreen'><b>LID</b></font> with inhibitor (1R)-menthyl hexyl phosphonate (<b><font color='#909090'>C</font> <font color='#ff0d0d'>O</font> <font color='#ff8000'>P</font></b>).
+A morph<ref>This is a [[Morphs#Linear_Interpolation|linear interpolation morph]]. The 14-model PDB file is [[Image:Morph-linear-1trh-1lpm.pdb.gz]].</ref> shows the lid opening and closing.
+*<scene name='Lipase_lid_morph/Lightseagreen_hinge/2'>Cartoon morph</scene> (<font color='lightseagreen'><b>LID</b></font>).
+*<scene name='Lipase_lid_morph/Lightseagreen_hinge/3'>Spacefilling morph</scene> (<font color='lightseagreen'><b>LID</b></font>, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />).<br>
+{{Template:Button Toggle Animation2}}
+When the lid is closed, the enzyme surface is largely {{Template:ColorKey_Polar}}. When the lid opens, a {{Template:ColorKey_Hydrophobic}} pocket is exposed with the catalytic triad in the bottom.
+*<scene name='Lipase_lid_morph/Lightseagreen_hinge/5'>Spacefilling morph</scene> ({{Template:ColorKey_Polar}}, {{Template:ColorKey_Hydrophobic}}, <font color='orange'><b>catalytic triad: Ser209, Glu341, and His449</b></font><ref name='2states1994' />).
+==See Also==
+*[[Lipase]], the main article in Proteopedia.
+*[[Molecular Playground/Pancreatic Lipase]]
+*[http://en.wikipedia.org/wiki/Lipase Lipase in Wikipedia]
+==Notes and References==
+<references />