Nerve growth factor: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref... |
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<StructureSection load='1www' size='340' side='right' caption='Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code [[1www]])' scene='84/845929/Cv/1'> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
'''Nerve growth factor''' (NGF) belongs to the family of neurotrophins. NGF promotes survival and differentiation of sensory and sympathetic neurons. NGF signaling furthers neuroprotective and repair functions<ref>PMID:11520933</ref>. NGF interacts with 2 transmembrane receptors - TrkA and p75. | |||
== Relevance == | == Relevance == | ||
Increased cerebrospinal fluid levels of proNGF mark the onset of mild cognitive impairment and the transition to Alzheimer disease suggest that NGF is a potential Alzheimer biomarker<ref>PMID:31312116</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the <scene name='84/845929/Cv/4'>receptor D-5 domain Ig-like structure</scene> flanking the <scene name='84/845929/Cv/5'>NGF homodimer</scene>. Various side chains form the <scene name='84/845929/Cv/10'>interactions between NGF and its receptor</scene> with a <scene name='84/845929/Cv/11'>totally buried NGF Arg residue forming the strongest one</scene><ref>PMID:10490030</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | </StructureSection> | ||
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==3D structures of nerve growth factor== | ==3D structures of nerve growth factor== | ||
[[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[6yw8]] - hβ-NGF – human - NMR<br /> | |||
[[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody<br /> | |||
[[2ifg]], [[1www]] - hβ-NGF + TrkA<br /> | [[2ifg]], [[1www]] - hβ-NGF + TrkA<br /> | ||
[[1sg1]] - hβ-NGF + neutrophin receptor<br /> | [[1sg1]] - hβ-NGF + neutrophin receptor<br /> | ||
[[4zbn]] - hβ-NGF + DNA<br /> | [[4zbn]] - hβ-NGF + DNA<br /> | ||
[[6xuo]] - NGF - horse<br /> | [[6xuo]] - NGF - horse<br /> | ||
[[ | [[1bet]], [[1btg]], [[1sgf]], [[5lsd]] - mNGF - mouse<br /> | ||
[[4xpj]] - mNGF + | [[4eax]], [[4xpj]] - mNGF + lipid<br /> | ||
[[4ec7]] - NGF - cobra<br /> | [[6ffy]] - mNGF + SorCS2<br /> | ||
[[3ij2]] - mNGF + TNFR<br /> | |||
[[4ec7]] - NGF + lipid - cobra<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
Latest revision as of 08:55, 24 March 2026
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3D structures of nerve growth factor
Updated on 24-March-2026
6yw8 - hβ-NGF – human - NMR
4edk, 4edw, 5jz7 - hβ-NGF + antibody
2ifg, 1www - hβ-NGF + TrkA
1sg1 - hβ-NGF + neutrophin receptor
4zbn - hβ-NGF + DNA
6xuo - NGF - horse
1bet, 1btg, 1sgf, 5lsd - mNGF - mouse
4eax, 4xpj - mNGF + lipid
6ffy - mNGF + SorCS2
3ij2 - mNGF + TNFR
4ec7 - NGF + lipid - cobra
