Nerve growth factor: Difference between revisions

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<StructureSection load='1www' size='340' side='right' caption='Human NGF (purple, khaki) complex with TrkA receptor domain 5 (azure, mustard) (PDB code [[1www]])' scene=''>
<StructureSection load='1www' size='340' side='right' caption='Human NGF (green, yellowgreen) complex with TrkA receptor domain 5 (cyan, deepskyblue) (PDB code [[1www]])' scene='84/845929/Cv/1'>


== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==


The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the receptor D-5 domain Ig-like structure flanking the NGF homodimer. Various side chains form the interaction between NGF and its receptor with a totally buried NGF Arg residue forming the strongest one<ref>PMID:10490030</ref>.
The 3D structure of the complex between human NGF and one of its receptors - TrkA - shows the <scene name='84/845929/Cv/4'>receptor D-5 domain Ig-like structure</scene> flanking the <scene name='84/845929/Cv/5'>NGF homodimer</scene>. Various side chains form the <scene name='84/845929/Cv/10'>interactions between NGF and its receptor</scene> with a <scene name='84/845929/Cv/11'>totally buried NGF Arg residue forming the strongest one</scene><ref>PMID:10490030</ref>. Water molecules are shown as red spheres.


</StructureSection>
</StructureSection>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody - human<br />
[[6yw8]] - hβ-NGF – human - NMR<br />
[[4edk]], [[4edw]], [[5jz7]] - hβ-NGF + antibody<br />
[[2ifg]], [[1www]] - hβ-NGF + TrkA<br />
[[2ifg]], [[1www]] - hβ-NGF + TrkA<br />
[[1sg1]] - hβ-NGF + neutrophin receptor<br />
[[1sg1]] - hβ-NGF + neutrophin receptor<br />
[[4zbn]] - hβ-NGF + DNA<br />
[[4zbn]] - hβ-NGF + DNA<br />
[[6xuo]] - NGF - horse<br />
[[6xuo]] - NGF - horse<br />
[[1btg]], [[5lsd]], [[1sgf]], [[1bet]] - mNGF - mouse<br />
[[1bet]], [[1btg]], [[1sgf]], [[5lsd]] - mNGF - mouse<br />
[[4xpj]], [[4eax]] - mNGF + lipid<br />
[[4eax]], [[4xpj]] - mNGF + lipid<br />
[[6ffy]] - mNGF + SorCS2<br />
[[6ffy]] - mNGF + SorCS2<br />
[[3ij2]] - mNGF + TNFR<br />
[[3ij2]] - mNGF + TNFR<br />
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