5h12: Difference between revisions
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<StructureSection load='5h12' size='340' side='right'caption='[[5h12]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='5h12' size='340' side='right'caption='[[5h12]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5h12]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5h12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus Pyrococcus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H12 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h12 OCA], [https://pdbe.org/5h12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h12 RCSB], [https://www.ebi.ac.uk/pdbsum/5h12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h12 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DPOL_PYRSD DPOL_PYRSD] In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.[UniProtKB:P77933] Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein (Probable). Intein splicing has been shown to occur via a branched intermediate that is resolved as the reaction proceeds; formation of the branched intermediate is reversible in response to pH shifts (PubMed:8269515).<ref>PMID:8269515</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Pyrococcus]] | [[Category: Pyrococcus]] | ||
[[Category: Hikida | [[Category: Hikida Y]] | ||
[[Category: Hirao | [[Category: Hirao I]] | ||
[[Category: Kimoto | [[Category: Kimoto M]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
Latest revision as of 11:48, 2 August 2023
Crystal structure of Deep Vent DNA Polymerase
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