HPPK 3D structures

3D structures of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

Updated on 28-August-2024 - For a general description of the protein see 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

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• HPPK
  • 1hka, 1eq0 – EcHPPK – Escherichia coli
    
  • 1g4c, 1im6, 1kbr, 1rtz, 1tmj, 3hcx, 3hsd, 3hsj, 3hsz, 3ili, 3ill, 3kue, 3kug – EcHPPK (mutant)
    
  • 2f63, 2f65 – EcHPPK - NMR
    
  • 8sd5 – MjHPPK – Methanocaldococcus jannaschii
    
• HPPK binary complex
  • 1cbk – HPPK + dihydro-dimethyl-6-hydroxypterin – Haemophilus influenza
    
  • 1eqm – EcHPPK + ADP
    
  • 1ex8 – EcHPPK + adenosine-tetraphosphate-methyl-dihydropterin
    
  • 1rb0 – EcHPPK + 6-hydroxymethylpterin-diphosphate
    
  • 3hd1, 3hsg, 3ht0, 3ilj, 3kuh – EcHPPK (mutant) + methyleneadenosine-triphosphate
    
  • 3ud5, 3ude, 3udv, 4f7v, 6an4, 6an6, 7kdo, 7kdr, 8sif – EcHPPK + inhibitor
    
  • 4pzv - HPPK/DHPS + inhibitor - Francisella tularensis
    
  • 3qbc – SaHPPK + inhibitor – Staphylococcus aureus
    
  • 8sk1 – HPPK + inhibitor – Bacillus anthracis
    
  • 8sbu – MjHPPK/MBP
    
• HPPK ternary complex
  • 1ru2, 1tmm – EcHPPK (mutant) + ATP derivative + 6-hydroxymethylpterin
    
  • 1dy3 – EcHPPK (mutant) + ATP + pteridine derivative
    
  • 3ip0 – EcHPPK + ATP derivative + pteridine derivative
    
  • 1f9h, 1hq2, 1q0n, 1ru1, 3ilo – EcHPPK (mutant) + ATP derivative + pteridine derivative
    
  • 3hd2 – EcHPPK (mutant) + ATP derivative + pterine
    
  • 4m5g, 4m5h, 4m5i, 4m5j, 4m5k, 4m5l, 4m5m, 4m5n – EcHPPK + ATP derivative + inhibitor
    
  • 1rao – EcHPPK (mutant) + AMP + 6-hydroxymethylpterin-diphosphate
    
  • 5etl, 5etm, 5etn, 5eto, 5etp, 5etq, 5etr, 5ets, 5ett, 5etv - EcHPPK + AMPCPP + inhibitor
    
  • 4crj, 4cwb, 4cyu - SaHPPK + AMPCPP + inhibitor
    
  • 2qx0 – HPPK + ATP derivative, 5etk, 5etl, 5etm, 5etn, 5eto, 5etp, 5etq, 5etr, 5ets, 5ett, 5etv + pteridine derivative – Yersinia pestis
    
• HPPK-DHPS
  • 7mpy – HPPK-DHPS – Arabidopsis thaliana
    
  • 5z79 – HPPK-DHPS + ATP derivative + pteridine derivative + pterine + adenosine derivative + 4-aminobenzoic acid – Plasmodium vivax
    
  • 3mcm – FtHPPK-DHPS – Francisella tularensis
    
  • 3mcn, 8sl9 – FtHPPK-DHPS + inhibitor
    
  • 4pzv – FtHPPK-DHPS + bisubstrate inhibitor
    
  • 3mco – FtHPPK-DHPS + ATP derivative
    
  • 6jwu, 6jwx – PfHPPK-DHPS + AMP + pteridine derivative – Plasmodium falciparum
    
  • 6jwq – PfHPPK-DHPS + ATP + AMP
    
  • 6jws, 6jwt – PfHPPK-DHPS (mutant) + ATP + pteroate
    
  • 6jwr – PfHPPK-DHPS (mutant) + AMP + pteroate
    
  • 6jwz – PfHPPK-DHPS (mutant) + AMP + pteridine derivative
    
  • 6jwv, 6jwy – PfHPPK-DHPS (mutant) + ATP + pteridine derivative
    
  • 6jww – PfHPPK-DHPS (mutant) + ATP + AMP + pteridine derivative
    
  • 6kck – PfHPPK-DHPS + ATP derivative + pterine + hydroxybenzoate
    
  • 6kcl, 6kcm – PfHPPK-DHPS (mutant) + ATP derivative + pterine + hydroxybenzoate
    

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Michal Harel