7c4o: Difference between revisions

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New page: '''Unreleased structure''' The entry 7c4o is ON HOLD until Paper Publication Authors: Fan, J.S., Nayak, A., Swaminathan, K. Description: Solution structure of the Orange domain from hu...
 
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'''Unreleased structure'''


The entry 7c4o is ON HOLD  until Paper Publication
==Solution structure of the Orange domain from human protein HES1==
 
<StructureSection load='7c4o' size='340' side='right'caption='[[7c4o]]' scene=''>
Authors: Fan, J.S., Nayak, A., Swaminathan, K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7c4o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C4O FirstGlance]. <br>
Description: Solution structure of the Orange domain from human protein HES1
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c4o OCA], [https://pdbe.org/7c4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c4o RCSB], [https://www.ebi.ac.uk/pdbsum/7c4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c4o ProSAT]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Fan, J.S]]
== Function ==
[[Category: Nayak, A]]
[https://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref>
[[Category: Swaminathan, K]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Fan JS]]
[[Category: Nayak A]]
[[Category: Swaminathan K]]
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