6u4y: Difference between revisions

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'''Unreleased structure'''


The entry 6u4y is ON HOLD  until Paper Publication
==Crystal Structure of an EZH2-EED Complex in an Oligomeric State==
<StructureSection load='6u4y' size='340' side='right'caption='[[6u4y]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6u4y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U4Y FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u4y OCA], [https://pdbe.org/6u4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u4y RCSB], [https://www.ebi.ac.uk/pdbsum/6u4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u4y ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN] Weaver syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/EZH2_HUMAN EZH2_HUMAN] Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA.<ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16179254</ref> <ref>PMID:16618801</ref> <ref>PMID:16357870</ref> <ref>PMID:16936726</ref> <ref>PMID:17210787</ref> <ref>PMID:17344414</ref> <ref>PMID:19026781</ref> <ref>PMID:18285464</ref> <ref>PMID:20935635</ref> <ref>PMID:23063525</ref>


Authors: Jiao, L., Liu, X.
==See Also==
 
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
Description: Crystal Structure of an EZH2-EED Complex in an Oligomeric State
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
[[Category: Unreleased Structures]]
== References ==
[[Category: Jiao, L]]
<references/>
[[Category: Liu, X]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jiao L]]
[[Category: Liu X]]
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