5imu: Difference between revisions

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<StructureSection load='5imu' size='340' side='right'caption='[[5imu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5imu' size='340' side='right'caption='[[5imu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5imu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IMU FirstGlance]. <br>
<table><tr><td colspan='2'>[[5imu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IMU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv3899c, LH57_21230 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5imu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imu OCA], [http://pdbe.org/5imu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5imu RCSB], [http://www.ebi.ac.uk/pdbsum/5imu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5imu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5imu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imu OCA], [https://pdbe.org/5imu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5imu RCSB], [https://www.ebi.ac.uk/pdbsum/5imu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5imu ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/O05446_MYCTU O05446_MYCTU]
Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c(184-410), a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an alpha/beta/alpha sandwich folding domain and an alpha-helix bundle domain. There are no reported protein structures for any Rv3899c homologues; this structure provides the first structural glimpse of a new protein family consisting of Rv3899c and its homologues.
 
Crystal structure of Rv3899c(184-410), a hypothetical protein from Mycobacterium tuberculosis.,Liu Y, Gao Y, Li D, Fleming J, Li H, Bi L Acta Crystallogr F Struct Biol Commun. 2016 Aug;72(Pt 8):642-5. doi:, 10.1107/S2053230X16010943. Epub 2016 Jul 27. PMID:27487929<ref>PMID:27487929</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5imu" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Bi, L J]]
[[Category: Bi LJ]]
[[Category: Gao, Y R]]
[[Category: Gao YR]]
[[Category: Li, D F]]
[[Category: Li DF]]
[[Category: Liu, Y Y]]
[[Category: Liu YY]]
[[Category: Alpha helix bundule]]
[[Category: Alpha/beta/alpha sandwich]]
[[Category: Signaling protein]]

Latest revision as of 09:16, 20 March 2024

A fragment of conserved hypothetical protein Rv3899c (residues 184-410) from Mycobacterium tuberculosis

5imu, resolution 1.90Å

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