6vrc: Difference between revisions
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==Cryo-EM structure of Cas13(crRNA)== | ==Cryo-EM structure of Cas13(crRNA)== | ||
<StructureSection load='6vrc' size='340' side='right'caption='[[6vrc]]' scene=''> | <StructureSection load='6vrc' size='340' side='right'caption='[[6vrc]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRC OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6vrc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_seeligeri_serovar_1/2b_str._SLCC3954 Listeria seeligeri serovar 1/2b str. SLCC3954]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VRC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VRC FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vrc OCA], [https://pdbe.org/6vrc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vrc RCSB], [https://www.ebi.ac.uk/pdbsum/6vrc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vrc ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CS13A_LISSS CS13A_LISSS] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. Unlike many single-component effectors, this CRISPR-Cas system targets RNA (By similarity). CRISPR clusters are transcribed from pre-CRISPR RNA (crRNA) and processed into crRNA by this protein (PubMed:27669025).[UniProtKB:P0DOC6]<ref>PMID:27669025</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Listeria seeligeri serovar 1/2b str. SLCC3954]] | |||
[[Category: Jia N]] | [[Category: Jia N]] | ||
[[Category: Marraffini LA]] | [[Category: Marraffini LA]] | ||
[[Category: Meeske AJ]] | [[Category: Meeske AJ]] | ||
[[Category: Patel DJ]] | [[Category: Patel DJ]] | ||
Latest revision as of 14:39, 6 March 2024
Cryo-EM structure of Cas13(crRNA)
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