6x0m: Difference between revisions

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'''Unreleased structure'''


The entry 6x0m is ON HOLD  until Paper Publication
==Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin==
<StructureSection load='6x0m' size='340' side='right'caption='[[6x0m]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6x0m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6X0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6X0M FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6x0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6x0m OCA], [https://pdbe.org/6x0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6x0m RCSB], [https://www.ebi.ac.uk/pdbsum/6x0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6x0m ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPF1_HUMAN HPF1_HUMAN] Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine (PubMed:28190768, PubMed:29480802). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:30257210).<ref>PMID:27067600</ref> <ref>PMID:28190768</ref> <ref>PMID:29480802</ref> <ref>PMID:30257210</ref>


Authors:  
==See Also==
 
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
Description:  
== References ==
[[Category: Unreleased Structures]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Bilokapic S]]
[[Category: Halic M]]
Retrieved from "https://proteopedia.org/6x0m"