7ca4: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 7ca4 is ON HOLD Authors: Wang, F., Lv, Z., Lin, D., Huang, Y. Description: The Crystal Structure of human Bcl-2-like protein 1 from Wuxi Biortus. [... |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
The | ==The Crystal Structure of human Bcl-2-like protein 1 from Biortus== | ||
<StructureSection load='7ca4' size='340' side='right'caption='[[7ca4]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ca4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CA4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ca4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ca4 OCA], [https://pdbe.org/7ca4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ca4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ca4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ca4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | |||
==See Also== | |||
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Huang | __TOC__ | ||
[[Category: Lin | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Huang Y]] | |||
[[Category: Lin D]] | |||
[[Category: Lv Z]] | |||
[[Category: Wang F]] | |||
Latest revision as of 16:01, 29 November 2023
The Crystal Structure of human Bcl-2-like protein 1 from Biortus
| ||||||||||||
