2va7: Difference between revisions
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<StructureSection load='2va7' size='340' side='right'caption='[[2va7]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2va7' size='340' side='right'caption='[[2va7]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2va7]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2va7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VA7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C27:(6R)-2-AMINO-6-[2-(3-METHOXYBIPHENYL-3-YL)ETHYL]-3,6-DIMETHYL-5,6-DIHYDROPYRIMIDIN-4(3H)-ONE'>C27</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C27:(6R)-2-AMINO-6-[2-(3-METHOXYBIPHENYL-3-YL)ETHYL]-3,6-DIMETHYL-5,6-DIHYDROPYRIMIDIN-4(3H)-ONE'>C27</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2va7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2va7 OCA], [https://pdbe.org/2va7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2va7 RCSB], [https://www.ebi.ac.uk/pdbsum/2va7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2va7 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/va/2va7_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/va/2va7_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aharony D]] | |||
[[Category: Aharony | [[Category: Albert JS]] | ||
[[Category: Albert | [[Category: Andisik D]] | ||
[[Category: Andisik | [[Category: Callaghan O]] | ||
[[Category: Callaghan | [[Category: Campbell JB]] | ||
[[Category: Campbell | [[Category: Carr RA]] | ||
[[Category: Carr | [[Category: Chessari G]] | ||
[[Category: Chessari | [[Category: Congreve M]] | ||
[[Category: Congreve | [[Category: Edwards PD]] | ||
[[Category: Edwards | [[Category: Folmer RHA]] | ||
[[Category: Folmer | [[Category: Frederickson M]] | ||
[[Category: Frederickson | [[Category: Geschwindner S]] | ||
[[Category: Geschwindner | [[Category: Koether G]] | ||
[[Category: Koether | [[Category: Kolmodin K]] | ||
[[Category: Kolmodin | [[Category: Krumrine J]] | ||
[[Category: Krumrine | [[Category: Mauger RC]] | ||
[[Category: Mauger | [[Category: Murray CW]] | ||
[[Category: Murray | [[Category: Olsson LL]] | ||
[[Category: Olsson | [[Category: Patel S]] | ||
[[Category: Patel | [[Category: Spear N]] | ||
[[Category: Spear | [[Category: Sylvester M]] | ||
[[Category: Sylvester | [[Category: Tian G]] | ||
[[Category: Tian | |||
