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New page: left|200px<br /> <applet load="1bii" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bii, resolution 2.4Å" /> '''THE CRYSTAL STRUCTUR...
 
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[[Image:1bii.gif|left|200px]]<br />
<applet load="1bii" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1bii, resolution 2.4&Aring;" />
'''THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110'''<br />


==Overview==
==THE CRYSTAL STRUCTURE OF H-2DD MHC CLASS I IN COMPLEX WITH THE HIV-1 DERIVED PEPTIDE P18-110==
The structure of H-2Dd complexed with the HIV-derived peptide P18-I10, (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A, resolution. This MHC class I molecule has an unusual binding motif with, four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10)., The cleft architecture of H-2Dd includes a deep narrow passage, accomodating the N-terminal part of the peptide, explaining the obligatory, G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V, form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional, data available for T cell and natural killer cell recognition of the H-2Dd, molecule.
<StructureSection load='1bii' size='340' side='right'caption='[[1bii]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bii]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BII OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BII FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bii OCA], [https://pdbe.org/1bii PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bii RCSB], [https://www.ebi.ac.uk/pdbsum/1bii PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bii ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HA12_MOUSE HA12_MOUSE] Involved in the presentation of foreign antigens to the immune system.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bi/1bii_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bii ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includes a deep narrow passage accomodating the N-terminal part of the peptide, explaining the obligatory G2P3 anchor motif. Toward the C-terminal half of the peptide, p5R to p8V form a type I' reverse turn; residues p6A to p9T, and in particular p7F, are readily exposed. The structure is discussed in relation to functional data available for T cell and natural killer cell recognition of the H-2Dd molecule.


==About this Structure==
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.,Achour A, Persson K, Harris RA, Sundback J, Sentman CL, Lindqvist Y, Schneider G, Karre K Immunity. 1998 Aug;9(2):199-208. PMID:9729040<ref>PMID:9729040</ref>
1BII is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BII OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition., Achour A, Persson K, Harris RA, Sundback J, Sentman CL, Lindqvist Y, Schneider G, Karre K, Immunity. 1998 Aug;9(2):199-208. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9729040 9729040]
</div>
<div class="pdbe-citations 1bii" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Achour A]]
[[Category: Achour, A.]]
[[Category: Harris RA]]
[[Category: Harris, R.A.]]
[[Category: Karre K]]
[[Category: Karre, K.]]
[[Category: Lindqvist Y]]
[[Category: Lindqvist, Y.]]
[[Category: Persson K]]
[[Category: Persson, K.]]
[[Category: Schneider G]]
[[Category: Schneider, G.]]
[[Category: Sentman CL]]
[[Category: Sentman, C.L.]]
[[Category: Sundback J]]
[[Category: Sundback, J.]]
[[Category: complex (mhc i/peptide)]]
[[Category: glycoprotein]]
[[Category: major histocompatibility complex class i dd]]
[[Category: transmembrane]]
 
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Retrieved from "https://proteopedia.org/1bii"