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[[Image:1bn0.gif|left|200px]]


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==SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES==
The line below this paragraph, containing "STRUCTURE_1bn0", creates the "Structure Box" on the page.
<StructureSection load='1bn0' size='340' side='right'caption='[[1bn0]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1bn0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BN0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bn0 OCA], [https://pdbe.org/1bn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bn0 RCSB], [https://www.ebi.ac.uk/pdbsum/1bn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bn0 ProSAT]</span></td></tr>
{{STRUCTURE_1bn0| PDB=1bn0  |  SCENE= }}
</table>
 
<div style="background-color:#fffaf0;">
'''SL3 HAIRPIN FROM THE PACKAGING SIGNAL OF HIV-1, NMR, 11 STRUCTURES'''
== Publication Abstract from PubMed ==
 
 
==Overview==
An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.
An NMR-based structure is presented for a 20 mer hairpin model of the SL3 stem-loop from the HIV-1 packaging signal. The stem has an A-family structure. However, the GGAG tetraloop appears to be flexible with the second (G10) and fourth (G12) bases extruded from the normal stacking arrangement. The A-base (A11) occupies a cavity large enough for it to jump rapidly between stacking upon G9 (in the loop) and G13 (from the base-pair adjacent to the loop). The H-bonding loci of G10, A11, and G12 are unoccupied in the free RNA structure. The loop should be easily adaptable to binding by the HIV-1 nucleocapsid protein or loop receptors.


==About this Structure==
Three-dimensional folding of an RNA hairpin required for packaging HIV-1.,Pappalardo L, Kerwood DJ, Pelczer I, Borer PN J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:9743628<ref>PMID:9743628</ref>
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BN0 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Three-dimensional folding of an RNA hairpin required for packaging HIV-1., Pappalardo L, Kerwood DJ, Pelczer I, Borer PN, J Mol Biol. 1998 Oct 2;282(4):801-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9743628 9743628]
</div>
[[Category: Borer, P N.]]
<div class="pdbe-citations 1bn0" style="background-color:#fffaf0;"></div>
[[Category: Kerwood, D J.]]
== References ==
[[Category: Pappalardo, L.]]
<references/>
[[Category: Pelczer, I.]]
__TOC__
[[Category: Hiv-1]]
</StructureSection>
[[Category: Nmr]]
[[Category: Large Structures]]
[[Category: Packaging]]
[[Category: Borer PN]]
[[Category: Ribonucleic acid]]
[[Category: Kerwood DJ]]
[[Category: Rna]]
[[Category: Pappalardo L]]
[[Category: Tetraloop]]
[[Category: Pelczer I]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 11:43:04 2008''
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