1csl: Difference between revisions

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New page: left|200px<br /> <applet load="1csl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1csl, resolution 1.60Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:1csl.gif|left|200px]]<br />
<applet load="1csl" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1csl, resolution 1.60&Aring;" />
'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE'''<br />


==Overview==
==CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE==
The crystal structure of a 28 nt RNA fragment containing the human, immunodeficiency virus type 1 (HIV-1) Rev response element high affinity, binding site for Rev protein has been solved at 1.6 A resolution. The, overall structure of the RRE helix is greatly distorted from A-form, geometry by the presence of two purine-purine base-pairs and two single, nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair, with G71 adopting a syn conformation. The non-canonical regions in the, unliganded Rev response element molecule narrow the major groove width, with respect to standard A-RNA. The Rev response element structure, observed here represents a closed form of the Rev binding site and differs, from conformations of the RNA observed previously by solution NMR studies.
<StructureSection load='1csl' size='340' side='right'caption='[[1csl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1csl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CSL FirstGlance]. <br>
1CSL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [https://pdbe.org/1csl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB], [https://www.ebi.ac.uk/pdbsum/1csl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1csl ProSAT]</span></td></tr>
==Reference==
</table>
The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10656783 10656783]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Ippolito, J.A.]]
[[Category: Large Structures]]
[[Category: Steitz, T.A.]]
[[Category: Ippolito JA]]
[[Category: hiv-1]]
[[Category: Steitz TA]]
[[Category: rre high affinity site]]
 
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