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| [[Image:1bov.gif|left|200px]] | | #REDIRECT [[2xsc]] This PDB entry is obsolete and replaced by 2xsc |
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| {{STRUCTURE_1bov| PDB=1bov | SCENE= }}
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| '''CRYSTAL STRUCTURE OF THE CELL-BINDING B OLIGOMER OF VEROTOXIN-1 FROM E. COLI'''
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| ==Overview==
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| The Shiga toxin family, a group of cytotoxins associated with diarrhoeal diseases and the haemolytic uraemic syndrome, includes Shiga toxin from Shigella dysenteriae type 1 and verotoxins produced by enteropathogenic Escherichia coli. The family belongs to the A-B class of bacterial toxins, which includes the cholera toxin family, pertussis and diphtheria toxins. These toxins all have bipartite structures consisting of an enzymatic A subunit associated with a B oligomer which binds to specific cell-surface receptors, but their amino-acid sequences and pathogenic mechanisms differ. We have determined the crystal structure of the B oligomer of verotoxin-1 from E. coli. The structure unexpectedly resembles that of the B oligomer of the cholera toxin-like heat-labile enterotoxin from E. coli, despite the absence of detectable sequence similarity between these two proteins. This result implies a distant evolutionary relationship between the Shiga toxin and cholera toxin families. We suggest that the cell surface receptor-binding site lies in a cleft between adjacent subunits of the B pentamer, providing a potential target for drugs and vaccines to prevent toxin binding and effect.
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| ==About this Structure==
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| 1BOV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BOV OCA].
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| ==Reference==
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| Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli., Stein PE, Boodhoo A, Tyrrell GJ, Brunton JL, Read RJ, Nature. 1992 Feb 20;355(6362):748-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1741063 1741063]
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| [[Category: Escherichia coli]]
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| [[Category: Single protein]]
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| [[Category: Read, R J.]]
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| [[Category: Stein, P E.]]
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| [[Category: Toxin]]
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| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:46:53 2008''
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