6zfw: Difference between revisions
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New page: '''Unreleased structure''' The entry 6zfw is ON HOLD Authors: Softley, C.A., Ostertag, M.O., Sattler, M., Popowicz, G.P. Description: X-ray structure of the soluble N-terminal domain o... |
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The | ==X-ray structure of the soluble N-terminal domain of T. cruzi PEX-14== | ||
<StructureSection load='6zfw' size='340' side='right'caption='[[6zfw]], [[Resolution|resolution]] 1.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6zfw]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZFW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZFW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zfw OCA], [https://pdbe.org/6zfw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zfw RCSB], [https://www.ebi.ac.uk/pdbsum/6zfw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zfw ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q4D1H5_TRYCC Q4D1H5_TRYCC] Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.[RuleBase:RU367032] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We develop a residual deep learning model, hotWater (https://pypi.org/project/hotWater/), to identify key water interaction sites on proteins for binding models and drug discovery. This is tested on new crystal structures, as well as cryo-EM and NMR structures from the PDB and in crystallographic refinement with promising results. | |||
Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data.,Zaucha J, Softley CA, Sattler M, Frishman D, Popowicz GM Chem Commun (Camb). 2020 Nov 25. doi: 10.1039/d0cc04383d. PMID:33237041<ref>PMID:33237041</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6zfw" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Popowicz | <references/> | ||
[[Category: Sattler | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Trypanosoma cruzi]] | |||
[[Category: Ostertag MO]] | |||
[[Category: Popowicz GP]] | |||
[[Category: Sattler M]] | |||
[[Category: Softley CA]] | |||
Latest revision as of 13:48, 24 January 2024
X-ray structure of the soluble N-terminal domain of T. cruzi PEX-14
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