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[[Image:1bwm.gif|left|200px]]
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{{STRUCTURE_1bwm|  PDB=1bwm  |  SCENE=  }}
'''A SINGLE-CHAIN T CELL RECEPTOR'''


==A SINGLE-CHAIN T CELL RECEPTOR==
<StructureSection load='1bwm' size='340' side='right'caption='[[1bwm]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1bwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BWM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bwm OCA], [https://pdbe.org/1bwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bwm RCSB], [https://www.ebi.ac.uk/pdbsum/1bwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bwm ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5R1G1_MOUSE Q5R1G1_MOUSE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/1bwm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1bwm ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.


==Overview==
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.,Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364<ref>PMID:10360364</ref>
Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1BWM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].
</div>
<div class="pdbe-citations 1bwm" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor., Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G, Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10360364 10360364]
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Hare BJ]]
[[Category: Hare, B J.]]
[[Category: Reinherz EL]]
[[Category: Reinherz, E L.]]
[[Category: Wagner G]]
[[Category: Wagner, G.]]
[[Category: Wyss DF]]
[[Category: Wyss, D F.]]
[[Category: Immunoglobulin]]
[[Category: Immunoreceptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:02:39 2008''
Retrieved from "https://proteopedia.org/1bwm"