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New page: left|200px<br /> <applet load="1hvi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hvi, resolution 1.8Å" /> '''INFLUENCE OF STEREOC...
 
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[[Image:1hvi.gif|left|200px]]<br />
<applet load="1hvi" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1hvi, resolution 1.8&Aring;" />
'''INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE'''<br />


==About this Structure==
==INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE==
1HVI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with A77 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HVI OCA].  
<StructureSection load='1hvi' size='340' side='right'caption='[[1hvi]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1hvi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HVI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A77:N-{1-BENZYL-(2R,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE'>A77</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hvi OCA], [https://pdbe.org/1hvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hvi RCSB], [https://www.ebi.ac.uk/pdbsum/1hvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hvi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O92139_9HIV1 O92139_9HIV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/1hvi_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hvi ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
__TOC__
</StructureSection>
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Baldwin, E.T.]]
[[Category: Baldwin ET]]
[[Category: Bhat, T.N.]]
[[Category: Bhat TN]]
[[Category: Erickson, J.W.]]
[[Category: Erickson JW]]
[[Category: Hosur, M.V.]]
[[Category: Hosur MV]]
[[Category: A77]]
[[Category: hydrolase(acid protease)]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov  8 14:07:53 2007''
Retrieved from "https://proteopedia.org/1hvi"