7cgp: Difference between revisions
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The entry | ==Cryo-EM structure of the human mitochondrial translocase TIM22 complex at 3.7 angstrom.== | ||
<StructureSection load='7cgp' size='340' side='right'caption='[[7cgp]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7cgp]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CGP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEE:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cgp OCA], [https://pdbe.org/7cgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cgp RCSB], [https://www.ebi.ac.uk/pdbsum/7cgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cgp ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/TIM22_HUMAN TIM22_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TIM22_HUMAN TIM22_HUMAN] Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).[UniProtKB:Q12328] | |||
==See Also== | |||
*[[Diacylglycerol kinase 3D structures|Diacylglycerol kinase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Guan Z]] | |||
[[Category: Qi L]] | |||
[[Category: Wang Q]] | |||
[[Category: Yan C]] | |||
[[Category: Yin P]] | |||
Latest revision as of 09:27, 9 April 2025
Cryo-EM structure of the human mitochondrial translocase TIM22 complex at 3.7 angstrom.
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