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==Binary Complex of Human Glycerol 3-Phosphate Dehydrogenase, R269A mutant==
==Binary Complex of Human Glycerol 3-Phosphate Dehydrogenase, R269A mutant==
<StructureSection load='6pyp' size='340' side='right'caption='[[6pyp]]' scene=''>
<StructureSection load='6pyp' size='340' side='right'caption='[[6pyp]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PYP FirstGlance]. <br>
<table><tr><td colspan='2'>[[6pyp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PYP FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyp OCA], [http://pdbe.org/6pyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pyp RCSB], [http://www.ebi.ac.uk/pdbsum/6pyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyp ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SY:2,2-BIS(HYDROXYMETHYL)PROPANE-1,3-DIOL'>3SY</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pyp OCA], [https://pdbe.org/6pyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pyp RCSB], [https://www.ebi.ac.uk/pdbsum/6pyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pyp ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GPDA_HUMAN GPDA_HUMAN] Defects in GPD1 are a cause of hypertriglyceridemia, transient infantile (HTGTI) [MIM:[https://omim.org/entry/614480 614480]. An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis.<ref>PMID:22226083</ref>
== Function ==
[https://www.uniprot.org/uniprot/GPDA_HUMAN GPDA_HUMAN]
==See Also==
*[[Glycerol-3-phosphate dehydrogenase 3D structures|Glycerol-3-phosphate dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Gulick AM]]
[[Category: Gulick AM]]
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