1xap: Difference between revisions

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<StructureSection load='1xap' size='340' side='right'caption='[[1xap]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1xap' size='340' side='right'caption='[[1xap]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xap]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1XAP FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XAP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TTB:4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC+ACID'>TTB</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1xap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xap OCA], [http://pdbe.org/1xap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xap RCSB], [http://www.ebi.ac.uk/pdbsum/1xap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xap ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TTB:4-[(1E)-2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PROP-1-ENYL]BENZOIC+ACID'>TTB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xap OCA], [https://pdbe.org/1xap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xap RCSB], [https://www.ebi.ac.uk/pdbsum/1xap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xap ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RARB_HUMAN RARB_HUMAN]] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.<ref>PMID:12554770</ref>
[https://www.uniprot.org/uniprot/RARB_HUMAN RARB_HUMAN] Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.<ref>PMID:12554770</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Daris, J P]]
[[Category: Daris JP]]
[[Category: Germain, P]]
[[Category: De Lera AR]]
[[Category: Gronemeyer, H]]
[[Category: Germain P]]
[[Category: Kammerer, S]]
[[Category: Gronemeyer H]]
[[Category: Lapointe, P]]
[[Category: Kammerer S]]
[[Category: Lera, A R.De]]
[[Category: Lapointe P]]
[[Category: Marinier, A]]
[[Category: Marinier A]]
[[Category: Peluso-Iltis, C]]
[[Category: Peluso-Iltis C]]
[[Category: Rochel, N]]
[[Category: Rochel N]]
[[Category: Starrett, J]]
[[Category: Starrett J]]
[[Category: Tortolani, D]]
[[Category: Tortolani D]]
[[Category: Zusi, F C]]
[[Category: Zusi FC]]
[[Category: Ligand binding domain]]
[[Category: Nuclear receptor]]
[[Category: Retinoic acid receptor beta]]
[[Category: Transcription]]
[[Category: Ttnpb]]
Retrieved from "https://proteopedia.org/1xap"