5khj: Difference between revisions

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<StructureSection load='5khj' size='340' side='right'caption='[[5khj]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='5khj' size='340' side='right'caption='[[5khj]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5khj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KHJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[5khj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KHJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6SY:URIDINE-3,5-CYCLIC+MONOPHOSPHATE'>6SY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5khg|5khg]], [[5khh|5khh]], [[5khi|5khi]], [[5khk|5khk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6SY:URIDINE-3,5-CYCLIC+MONOPHOSPHATE'>6SY</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Hcn2, Bcng2, Hac1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5khj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khj OCA], [https://pdbe.org/5khj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5khj RCSB], [https://www.ebi.ac.uk/pdbsum/5khj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5khj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5khj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5khj OCA], [http://pdbe.org/5khj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5khj RCSB], [http://www.ebi.ac.uk/pdbsum/5khj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5khj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>
[https://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Accili, E A]]
[[Category: Accili EA]]
[[Category: Baronas, V]]
[[Category: Baronas V]]
[[Category: Ng, L C.T]]
[[Category: Ng LCT]]
[[Category: Petegem, F Van]]
[[Category: Putrenko I]]
[[Category: Putrenko, I]]
[[Category: Van Petegem F]]
[[Category: Cycilc nucleotide binding domain]]
[[Category: Ion transport]]
[[Category: Protein-ligand complex]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/5khj"