6z98: Difference between revisions

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'''Unreleased structure'''


The entry 6z98 is ON HOLD  until Paper Publication
==NMR solution structure of the peach allergen Pru p 1.0101==
<StructureSection load='6z98' size='340' side='right'caption='[[6z98]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6z98]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Amygdalus_persica Amygdalus persica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z98 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ypr-10, PR10, PRUPE_1G128700, PRUPE_ppa012651mg ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3760 Amygdalus persica])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z98 OCA], [https://pdbe.org/6z98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z98 RCSB], [https://www.ebi.ac.uk/pdbsum/6z98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z98 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Peach (Prunus persica) is among the fruits most frequently reported to cause food allergies. Allergic reactions commonly result from previous sensitization to the birch pollen allergen Bet v 1, followed by immunological cross-reactivity of IgE antibodies to structurally related proteins in peach. In this study, we present the three-dimensional NMR solution structure of the cross-reactive peach allergen Pru p 1 (isoform Pru p 1.0101). This 17.5 kDa protein adopts the canonical Bet v 1 fold, composed of a seven-stranded beta-sheet and three alpha-helices enclosing an internal cavity. In Pru p 1, the inner surface of the cavity contains an array of hydroxyl-bearing amino acids surrounded by a hydrophobic patch, constituting a docking site for amphiphilic molecules. NMR-guided docking of the cytokinin molecule zeatin to the internal cavity of Pru p 1 provides a structure-based rationale for the effect that zeatin binding has on the protein's RNase activity.


Authors: Eidelpes, R., Fuehrer, S., Hofer, F., Kamenik, A.S., Liedl, K.R., Tollinger, M.
Structure and Zeatin Binding of the Peach Allergen Pru p 1.,Eidelpes R, Hofer F, Rock M, Fuhrer S, Kamenik AS, Liedl KR, Tollinger M J Agric Food Chem. 2021 Jul 28;69(29):8120-8129. doi: 10.1021/acs.jafc.1c01876., Epub 2021 Jul 14. PMID:34260238<ref>PMID:34260238</ref>


Description: NMR solution structure of the peach allergen Pru p 1.0101
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Hofer, F]]
<div class="pdbe-citations 6z98" style="background-color:#fffaf0;"></div>
[[Category: Kamenik, A.S]]
== References ==
[[Category: Liedl, K.R]]
<references/>
__TOC__
</StructureSection>
[[Category: Amygdalus persica]]
[[Category: Large Structures]]
[[Category: Eidelpes, R]]
[[Category: Eidelpes, R]]
[[Category: Fuehrer, S]]
[[Category: Fuehrer, S]]
[[Category: Hofer, F]]
[[Category: Kamenik, A S]]
[[Category: Liedl, K R]]
[[Category: Tollinger, M]]
[[Category: Tollinger, M]]
[[Category: Allergen]]
[[Category: Cross-allergy]]
[[Category: Pathogenesis related protein]]
[[Category: Peach pru p 1 food allergen]]
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