1c94: Difference between revisions

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[[Image:1c94.jpg|left|200px]]


<!--
==REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.==
The line below this paragraph, containing "STRUCTURE_1c94", creates the "Structure Box" on the page.
<StructureSection load='1c94' size='340' side='right'caption='[[1c94]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1c94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C94 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c94 OCA], [https://pdbe.org/1c94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c94 RCSB], [https://www.ebi.ac.uk/pdbsum/1c94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c94 ProSAT]</span></td></tr>
{{STRUCTURE_1c94|  PDB=1c94  |  SCENE=  }}
</table>


'''REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.'''
==See Also==
 
*[[Gcn4 3D Structures|Gcn4 3D Structures]]
 
*[[Gnc4 3D Structures|Gnc4 3D Structures]]
==Overview==
__TOC__
The question of whether a protein whose natural sequence is inverted adopts a stable fold is still under debate. We have determined the 2. 1-A crystal structure of the retro-GCN4 leucine zipper. In contrast to the two-stranded helical coiled-coil GCN4 leucine zipper, the retro-leucine zipper formed a very stable, parallel four-helix bundle, which now lends itself to further structural and functional studies.
</StructureSection>
 
[[Category: Large Structures]]
==About this Structure==
[[Category: Deillon CA]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C94 OCA].
[[Category: Gruetter MG]]
 
[[Category: Gutte B]]
==Reference==
[[Category: Klauser S]]
The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure., Mittl PR, Deillon C, Sargent D, Liu N, Klauser S, Thomas RM, Gutte B, Grutter MG, Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2562-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10716989 10716989]
[[Category: Liu N]]
[[Category: Deillon, C A.]]
[[Category: Mittl PRE]]
[[Category: Gruetter, M G.]]
[[Category: Sargent D]]
[[Category: Gutte, B.]]
[[Category: Thomas RM]]
[[Category: Klauser, S.]]
[[Category: Liu, N.]]
[[Category: Mittl, P R.E.]]
[[Category: Sargent, D.]]
[[Category: Thomas, R M.]]
[[Category: 4-alpha-helix-bundle]]
[[Category: Peptide synthesis]]
[[Category: Retro-coiled coil]]
[[Category: X-ray structure]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:29:03 2008''

Latest revision as of 06:41, 7 February 2024

REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD.

1c94, resolution 2.08Å

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