1c9h: Difference between revisions

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[[Image:1c9h.gif|left|200px]]


<!--
==CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN==
The line below this paragraph, containing "STRUCTURE_1c9h", creates the "Structure Box" on the page.
<StructureSection load='1c9h' size='340' side='right'caption='[[1c9h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1c9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C9H FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RAP:RAPAMYCIN+IMMUNOSUPPRESSANT+DRUG'>RAP</scene></td></tr>
{{STRUCTURE_1c9h| PDB=1c9h |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9h OCA], [https://pdbe.org/1c9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c9h RCSB], [https://www.ebi.ac.uk/pdbsum/1c9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c9h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FKB1B_HUMAN FKB1B_HUMAN] Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/1c9h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c9h ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN'''
==See Also==
 
*[[FKBP 3D structures|FKBP 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
FKBP12.6 is a novel isoform of FKBP12, which selectively binds to the cardiac ryanodine receptor (RyR2). The crystal structure of FKBP12.6 in complex with rapamycin has now been determined at 2.0 A resolution. The structures of FKBP12.6 and FKBP12 are nearly identical, except for a displacement observed in the helical region of FKBP12.6 toward the hydrophobic pocket. This displacement was not predicted by homology modeling studies. Analyses of the residues that are likely to confer the RyR2-binding specificity are presented.
 
==About this Structure==
1C9H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C9H OCA].
 
==Reference==
Structure of FKBP12.6 in complex with rapamycin., Deivanayagam CC, Carson M, Thotakura A, Narayana SV, Chodavarapu RS, Acta Crystallogr D Biol Crystallogr. 2000 Mar;56(Pt 3):266-71. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10713512 10713512]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Carson, M.]]
[[Category: Carson M]]
[[Category: Chodavarapu, C S.]]
[[Category: Chodavarapu CS]]
[[Category: Deivanayagam, C C.S.]]
[[Category: Deivanayagam CCS]]
[[Category: Narayana, S V.L.]]
[[Category: Narayana SVL]]
[[Category: Thotakura, A.]]
[[Category: Thotakura A]]
[[Category: Complex]]
[[Category: Fkbp12]]
[[Category: Rapamycin]]
[[Category: Ryanodine receptor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 12:29:39 2008''

Latest revision as of 06:41, 7 February 2024

CRYSTAL STRUCTURE OF FKBP12.6 IN COMPLEX WITH RAPAMYCIN

1c9h, resolution 2.00Å

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