3b8e: Difference between revisions

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<StructureSection load='3b8e' size='340' side='right'caption='[[3b8e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='3b8e' size='340' side='right'caption='[[3b8e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3b8e]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The October 2009 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Sodium-Potassium Pump''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_10 10.2210/rcsb_pdb/mom_2009_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3B8E FirstGlance]. <br>
<table><tr><td colspan='2'>[[3b8e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The October 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Sodium-Potassium Pump''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_10 10.2210/rcsb_pdb/mom_2009_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B8E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MF4:TETRAFLUOROMAGNESATE(2-)'>MF4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MF4:TETRAFLUOROMAGNESATE(2-)'>MF4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8e OCA], [http://pdbe.org/3b8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3b8e RCSB], [http://www.ebi.ac.uk/pdbsum/3b8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8e OCA], [https://pdbe.org/3b8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b8e RCSB], [https://www.ebi.ac.uk/pdbsum/3b8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG]] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. [[http://www.uniprot.org/uniprot/AT1B1_PIG AT1B1_PIG]] This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.  
[https://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b8e_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b8e_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Sodium-Potassium Pump]]
[[Category: Sodium-Potassium Pump]]
[[Category: Sodium/potassium-exchanging ATPase]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Andersen, J P]]
[[Category: Andersen JP]]
[[Category: Morth, J P]]
[[Category: Morth JP]]
[[Category: Nissen, P]]
[[Category: Nissen P]]
[[Category: Pedersen, P B]]
[[Category: Pedersen PB]]
[[Category: Petersen, J]]
[[Category: Petersen J]]
[[Category: Soerensen, T L.M]]
[[Category: Soerensen TLM]]
[[Category: Toustrup-Jensen, M S]]
[[Category: Toustrup-Jensen MS]]
[[Category: Vilsen, B]]
[[Category: Vilsen B]]
[[Category: Atp-binding]]
[[Category: Calcium transport]]
[[Category: Cation pump]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Hydrolase-transport protein complex]]
[[Category: Ion transport]]
[[Category: K+-atpase]]
[[Category: Magnesium]]
[[Category: Membrane potential]]
[[Category: Membrane protein]]
[[Category: Metal-binding]]
[[Category: Na+]]
[[Category: Nucleotide-binding]]
[[Category: P-type atpase]]
[[Category: Phosphorylation]]
[[Category: Potassium]]
[[Category: Potassium transport]]
[[Category: Signal-anchor]]
[[Category: Sodium]]
[[Category: Sodium transport]]
[[Category: Sodium/potassium transport]]
[[Category: Transmembrane]]
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