High mobility group protein

spinqualitylabelsall models Rat HMGB1 tandem boxes complexed with DNA (PDB code 2gzk). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function High mobility group protein (HMG) is a chromatin protein which organizes the DNA and regulates transcription. HMG superfamilies differ by their DNA-binding domains. HMGAs bind via an AT-hook domain. For details on HMGA see HMGI(Y). HMGBs bind via box domain. HMGNs bind via a nucleosome binding domain. Disease Rearrangements of the HMGA2 gene were detected in human benign lipoma tumors. Relevance Overexpression of HMGB1 is associated with cancer and is targeted for cancer therapy.

3D Structures of high mobility group protein (HMG)

Updated on 26-August-2025

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• HMGA
  • HMGI(Y), 2eze, 2ezf, 2ezg – hHMG-1 + DNA - human
    
• HMGB box 1 domain residues 1-84; tandem boxes domain residues 1-166
  • 2yrq – hHMG-1 tandem boxes - human - NMR
    
  • 2rtu – hHMG-1 box 1 - NMR
    
  • 2ly4 – hHMG-1 box domain + cellular tumor antigen p53 - NMR
    
  • 6cij, 6cik, 6cil, 6cim – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA
    
  • 6cg0, 6oem, 6oen – hHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM
    
  • 8i9m – hHMG-1 89-183 + RAGE – Cryo EM
    
  • 9cg9 – hHMG-1 + nucleosome – Cryo EM
    
  • 2eqz, 2yqi – hHMG-3 box domain - NMR
    
  • 1j3d – pHMG-2 C terminal – pig - NMR
    
  • 1j3c – pHMG-2 C terminal (mutant) - NMR
    
  • 1j3x – pHMG-2 N terminal (mutant) - NMR
    
  • 1hme, 1hmf – rHMG-1 B domain – rat - NMR
    
  • 1aab – rHMG-1 A domain - NMR
    
  • 1ckt, 4qr9 – rHMG-1 A domain + DNA
    
  • 2gzk – rHMG-1 tandem boxes + DNA
    
  • 5zdz, 5ze0, 5ze1, 5ze2 – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – mouse
    
  • 6oeo, 6oer – mHMG-1 tandem boxes + RAG-1 + RAG-2 + DNA – Cryo EM
    
  • 1hsm, 1hsn, 1nhm, 1nhn – HMG-1 box domain – chinese hamster - NMR
    
  • 1hma – DmHMG-D DNA-binding domain – Drosophila melanogaster - NMR
    
  • 1qrv – DmHMG-D DNA-binding domain + DNA
    
  • 3nm9 – DmHMG-D DNA-binding domain (mutant) + DNA
    
  • 8r1x – DmHMG-D DNA-binding domain + DNA - NMR
    
• HMG
  • 2mrc – HMG residues 17-99 – Plasmodium falciparum - NMR
    

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Michal Harel, Joel L. Sussman