6tnb: Difference between revisions

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<StructureSection load='6tnb' size='340' side='right'caption='[[6tnb]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='6tnb' size='340' side='right'caption='[[6tnb]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6tnb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TNB FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TNB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TNB FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QW:(2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide'>8QW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QW:(2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide'>8QW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTK, MPS1, MPS1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnb OCA], [https://pdbe.org/6tnb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tnb RCSB], [https://www.ebi.ac.uk/pdbsum/6tnb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnb ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tnb OCA], [http://pdbe.org/6tnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tnb RCSB], [http://www.ebi.ac.uk/pdbsum/6tnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tnb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Activin receptor|Activin receptor]]
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bader, B]]
[[Category: Bader B]]
[[Category: Boemer, U]]
[[Category: Boemer U]]
[[Category: Bohlmann, R]]
[[Category: Bohlmann R]]
[[Category: Brands, M]]
[[Category: Brands M]]
[[Category: Briem, H]]
[[Category: Briem H]]
[[Category: Eberspaecher, U]]
[[Category: Eberspaecher U]]
[[Category: Fernandez-Montalvan, A]]
[[Category: Fernandez-Montalvan A]]
[[Category: Holton, S J]]
[[Category: Holton SJ]]
[[Category: Klar, U]]
[[Category: Klar U]]
[[Category: Koppitz, M]]
[[Category: Koppitz M]]
[[Category: Kosemund, D]]
[[Category: Kosemund D]]
[[Category: Marquardt, T]]
[[Category: Marquardt T]]
[[Category: Nguyen, D]]
[[Category: Nguyen D]]
[[Category: Nussbaum, F]]
[[Category: Nussbaum F]]
[[Category: Prechtl, S]]
[[Category: Prechtl S]]
[[Category: Schirok, H]]
[[Category: Schirok H]]
[[Category: Schulze, V K]]
[[Category: Schulze VK]]
[[Category: Siemeister, G]]
[[Category: Siemeister G]]
[[Category: Cell cycle]]
[[Category: Kinase]]
[[Category: Mps1]]
Retrieved from "https://proteopedia.org/6tnb"