Ketohexokinase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='3q92' size='350' side='right' caption='Human ketohexokinase complex with ihibitor and sulfate (PDB entry [[3q92]])' scene='48/484861/Cv/1'> | <StructureSection load='3q92' size='350' side='right' caption='Human ketohexokinase complex with ihibitor and sulfate (PDB entry [[3q92]])' scene='48/484861/Cv/1'> | ||
== Function == | == Function == | ||
'''Ketohexokinase''' (KHK) also known as '''hepatic fructokinase''' catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>. | '''Ketohexokinase''' (KHK) also known as '''hepatic fructokinase''' catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to '''HKH-A''' and the more active '''HKH-C'''. KHK acts in the first step of fructose metabolism<ref>PMID:2996495</ref>. | ||
== Disease == | == Disease == | ||
| Line 10: | Line 10: | ||
</StructureSection> | </StructureSection> | ||
==3D structures of ketohexokinase== | ==3D structures of ketohexokinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[2hlz]], [[2hqq]], [[3b3l]] – hKHK – human<br /> | [[2hlz]], [[2hqq]], [[3b3l]] – hKHK – human<br /> | ||
[[2hw1]], [[3nbv]] – hKHK + AMPPNP + fructose<br /> | [[2hw1]], [[3nbv]] – hKHK + AMPPNP + fructose<br /> | ||
[[3nbw]] – hKHK + pyrazole derivative<br /> | [[3nbw]] – hKHK + pyrazole derivative<br /> | ||
[[3nc2]], [[3nc9]], [[3nca]], [[3ro4]], [[3q92]], [[3qa2]], [[3qai]], [[5wbm]], [[5wbo]], [[5wbp]], [[5wbq]], [[5wbr]], [[5wbz]] – hKHK + inhibitor<br /> | [[3nc2]], [[3nc9]], [[3nca]], [[3ro4]], [[3q92]], [[3qa2]], [[3qai]], [[5wbm]], [[5wbo]], [[5wbp]], [[5wbq]], [[5wbr]], [[5wbz]], [[6w0n]], [[6w0w]], [[6w0x]], [[6w0y]], [[6w0z]] – hKHK + inhibitor<br /> | ||
[[ | [[8ome]] – hKHK-A + inhibitor | ||
[[8omf]], [[8omj]], [[8ug1]], [[8ug3]], [[9fhd]], [[9fhe]] – hKHK-C + inhibitor | |||
[[8omk]] – hKHK-C + ADP + fructose 1-phosphate<br /> | |||
[[6ul7]] - hKHK + osthole + fructose <br /> | |||
[[8omg]] – mKHK – mouse<br /> | |||
[[6p2d]] - mKHK + ADP + fructose <br /> | |||
[[8omd]] – mKHK + inhibitor | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:55, 19 October 2025
| ||||||||||||
3D structures of ketohexokinase
Updated on 19-October-2025
2hlz, 2hqq, 3b3l – hKHK – human
2hw1, 3nbv – hKHK + AMPPNP + fructose
3nbw – hKHK + pyrazole derivative
3nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai, 5wbm, 5wbo, 5wbp, 5wbq, 5wbr, 5wbz, 6w0n, 6w0w, 6w0x, 6w0y, 6w0z – hKHK + inhibitor
8ome – hKHK-A + inhibitor
8omf, 8omj, 8ug1, 8ug3, 9fhd, 9fhe – hKHK-C + inhibitor
8omk – hKHK-C + ADP + fructose 1-phosphate
6ul7 - hKHK + osthole + fructose
8omg – mKHK – mouse
6p2d - mKHK + ADP + fructose
8omd – mKHK + inhibitor
