7jl6: Difference between revisions
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==Heme binding to SrrB PAS domain plays a role in redox regulation of S. aureus SrrAB two-component system== | |||
<StructureSection load='7jl6' size='340' side='right'caption='[[7jl6]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7jl6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JL6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jl6 OCA], [https://pdbe.org/7jl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jl6 RCSB], [https://www.ebi.ac.uk/pdbsum/7jl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jl6 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Gakhar | == Function == | ||
[[Category: Sun | [https://www.uniprot.org/uniprot/SRRB_STAAU SRRB_STAAU] Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Plays also an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to SrrA. In turn, SrrA binds to the upstream promoter regions of the target genes to positively and negatively regulate their expression.[UniProtKB:Q5HFT1] | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Fuentes EJ]] | |||
[[Category: Gakhar L]] | |||
[[Category: Sun YJ]] | |||
[[Category: Tiwari N]] | |||
Latest revision as of 14:52, 6 March 2024
Heme binding to SrrB PAS domain plays a role in redox regulation of S. aureus SrrAB two-component system
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