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==Crystal Structure of Atg11 Coiled-Coil 3==
==Crystal Structure of Atg11 Coiled-Coil 3==
<StructureSection load='6vzf' size='340' side='right'caption='[[6vzf]]' scene=''>
<StructureSection load='6vzf' size='340' side='right'caption='[[6vzf]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VZF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VZF FirstGlance]. <br>
<table><tr><td colspan='2'>[[6vzf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VZF FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vzf OCA], [http://pdbe.org/6vzf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vzf RCSB], [http://www.ebi.ac.uk/pdbsum/6vzf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vzf ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vzf OCA], [https://pdbe.org/6vzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vzf RCSB], [https://www.ebi.ac.uk/pdbsum/6vzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vzf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATG11_YEAST ATG11_YEAST] Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for ATG9 anterograde transport from the mitochondria to the PAS. Recruits also the ATG19-prAPE1 complex to the PAS. Required for the Cvt vesicles completion. Plays a significant role in life span extension.<ref>PMID:10995454</ref> <ref>PMID:11264288</ref> <ref>PMID:11309418</ref> <ref>PMID:12479808</ref> <ref>PMID:15138258</ref> <ref>PMID:15659643</ref> <ref>PMID:16901900</ref> <ref>PMID:17012830</ref> <ref>PMID:17178909</ref> <ref>PMID:17192412</ref> <ref>PMID:17295840</ref> <ref>PMID:18077553</ref> <ref>PMID:18287526</ref> <ref>PMID:18497569</ref> <ref>PMID:18625846</ref> <ref>PMID:18701704</ref> <ref>PMID:18725539</ref> <ref>PMID:18818209</ref> <ref>PMID:19061865</ref> <ref>PMID:19371383</ref> <ref>PMID:19619494</ref> <ref>PMID:19619495</ref> <ref>PMID:20647741</ref> <ref>PMID:20855505</ref> <ref>PMID:21343297</ref> <ref>PMID:21429936</ref> <ref>PMID:21757540</ref> <ref>PMID:22157017</ref> <ref>PMID:22308029</ref> <ref>PMID:22509044</ref> <ref>PMID:22768199</ref> <ref>PMID:23337777</ref> <ref>PMID:23559066</ref> <ref>PMID:8663607</ref>
==See Also==
*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Margolis HK]]
[[Category: Margolis HK]]
[[Category: Ragusa MJ]]
[[Category: Ragusa MJ]]

Latest revision as of 14:40, 6 March 2024

Crystal Structure of Atg11 Coiled-Coil 3

6vzf, resolution 2.03Å

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